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Dual-acting antidepressant drugs

Duloxetine (Scheme 57.11) is an antidepressant drug that acts as a dual serotonin-norepinephrine reuptake inhibitor, the (5)-enantiomer being twice as potent as its counterpart. Both (/ )- and (5)-duloxetine have been prepared from ester (/ )-48, which in turn has been obtained by the DKR of the (3-hydroxynitrile rac-Al using CAL-B and Ru catalyst 3a. ... [Pg.1690]

All of the existing antidepressant drugs act through monoaminergic mechanisms, and further refinements are still possible in this arena. The concept of developing dual norepi-nephrine/serotonin uptake inhibitors, claimed for venlafaxine, has been adopted by other companies. Compounds with this profile are being developed by Eli-Lilly [duloxetine (50)]... [Pg.516]

See other pages where Dual-acting antidepressant drugs is mentioned: [Pg.112]    [Pg.361]    [Pg.112]    [Pg.401]    [Pg.33]    [Pg.268]    [Pg.845]    [Pg.401]    [Pg.27]    [Pg.4]    [Pg.250]    [Pg.1240]    [Pg.852]   


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Antidepressant drugs

Antidepressant drugs (antidepressants

Drugs acting

Dual-acting drugs

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