Drugs acting on the gastrointestinal tract. I Peptic ulcer

PKOTOH-rOJMP INHietTOES omeprazole lansoprazoie others 

The term peptic ulcer refers to an ulcer in an area where the niucusa is bathed in the hydrochloric add and pepsin of gastric juice (i.e. the stomach and upper part of the duodenum). Drugs that are effective in the treulmcnt of peptic ulcer cither reduce gastric acid secretion (left centre and righO or increase mucosat resistance to acid-pepsin attack (bottom left). 

Acid secretion from the park Ml ceils is reduced by II,- 

Antacids (top left) are bases that raise the gastric luminal pM by neutralizing gastric acid (middle left). Tliey provide effective trem-ment for many dyspepsias and symptomatic relief in peptic ulcer and oesophageal reflux. Many proprieiaiy mixtures which usually contain magnesium or aluminium. salu are available. 

Parietal cells secrete acid into the stomach lumen. This is achieved by a unit uc H /K -ATPa.sc (proton pump) that catalyses the exchange of intracellular for extracellular K . The secretion of HCI is. stimulated 

---

Drugs acting on the gastrointestinal tract, i Peptic ulcer... 

---