Release control, drugs

P. Colombo, R. Bettini, G. Massimg, et al. Drug diffusion front movements important in drug release control from swellable matrix tablet. J. Pharm. Sci. 84 991—997, 1995. 

Kikuchi, A., and Okano, T. (2002), Pulsatile drug release control using hydrogels, Adv. Drug Deliv. Rev., 54, 53-77. 

Second, the excipient percolation threshold in hydrophilic matrices represents the border between a fast release of the drug (below the threshold) and a drug release controlled by the formation of a coherent gel layer (above the excipient percolation threshold). Therefore, knowledge of this threshold will allow us to avoid the preparation of a number of unnecessary lots during the development of a pharmaceutical formulation, resulting in a reduction of the time to market. 

Miyazaki S, Yokouchi C, and Takada M. External control of drug release Controlled release of insulin from a hydrophilic pol3nner implant by ultrasound irradiation in diabetic rats. J. Pharm. Pharmacol. 1988 40 716-717. 

Sako K, Sawada T, Nakashima H, et al. Influence of water soluble fillers in hydroxypropylmethylcellulose matrices on in vitro and in vivo drug release. ] Control Release 2002 81 165-172. 

One of the interesting components of the drug release controlling effect of drug delivery polymer matrixes is the degradation of the polymer matrix in the biological medium, in consequence of which the active substance is released [37,38, 77-80] (Figures 18.17 and 18.18). 

Assay Impurities/degradation products (low levels, 0.1%) Impurities/degradation products (higher levels, 0.5%) Dissolution (immediate release) Dissolution/drug release (controlled release, multipoint specification) +/— 2% absolute difference between labs, 2% RSD for each sample/analyst +/— 40% relative or 0.1% absolute difference between labs +/— 25% relative difference between labs, 10% RSD for each sample/analyst +/— 5% absolute difference between labs at the Q time point 5-10% absolute difference between labs at each specified time point... 

M Zandi, A Pourjavadi, S A Hashemi, H Arabi, Preparation of ethyl cellulose microcapsules containing perphenazine and polymeric perphenazine based on acryloyl chloride for physical and chemical studies of drug release control . Polymer Int, 1998 47 413-418... 

Tien, C. L., Lacroix, M., Ispas-Szabo, P., and Mateescu, M. A. 2003. iV-acylated chitosan Hydrophobic matrices for controlled drug release. /. Control. Release 93(1) 1-13. 

With these hackgroimds, we can imderstand the critical importance of supramolecular chemistry in biomaterials nanoarchitectonics. In this chapter, we focus on supramolecular strategies for drug delivery functions as typical examples of biorelated and/or biomolecule-included examples. In addition to DDS and related functions using standard host-guest complexes and molecular assemblies, drug release controls from supramolecular materials by mechanical stimuli are included as forefront examples. 

PRESS-COATED SYSTEMS FOR DRUG RELEASE CONTROL... 

V. ubr, J. Strohalm, T. Hirano, Y. Ito and K. Ulbrich, Poly[N-(2-hydroxypropyl)methacrylamide] conjugates of methotrexate — Synthesis and in vitro drug release, /. Control. Release, 49,123-132 (1997). 

S. Pohja, E. Suihko, M. Vidgren, P. Paronen, and J. Ketolainen, Starch acetate as a tablet matrix for sustained drug release, /. Controlled Release, 94 (2-3), 293-302,2004. 

M. Nakayama, T. Okano, T. Miyazaki, F. Kohori, K. Sakai, and M. Yokoyama, Molecular design of biodegradable polymeric micelles for temperature-responsive drug release, / Control Release, 115 (1), 46-56, 2006. 

K. Chansanroj, J. Petrovic, S. Ibric, and G. Betz, Drug release control and system understanding of sucrose esters matrix tablets by artificial neural networks, Eur. J. Pharm. Sci.,... 

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