Carrier for Controlled-Release Drugs

Controlled release of therapeutics to the specific site over an extended period of time is an important determinant in delivery of active pharmaceutical ingredients. This local delivery reduces potential side effects as well as maximizes therapeutic effects by obtaining the optimal concentration of API in local sites. In recent years, the study of controlled release of API from polymeric devices, which are, e.g., silicone elastomers, has attracted many researchers. Controlled drug delivery applications include sustained delivery over days, weeks, months or years. The application 

In the literature three of the release mechanisms of drugs with different physiochem-ical properties from silicone carriers were described [63]  

As drug carrier, silicone plays role in a) matrix formulation, b) covered-rod formulation, and c) double-layered formulation [63]. 

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