Osmotically-controlled release, oral drug delivery

Comparative pharmacokinetic profiles of nifedipine delivered from Procardia XL, an osmotic pressure-controlled drug delivery system, once-a-day versus that from Procardia, an immediate-release dosage form, taken on time 0, 8 and 16 in human volunteers. Modified from Y.W. Chien. Oral drug delivery and delivery systems. Y.W.Chien (ed.) (1992) Novel Drug Delivery Systems. Marcel Dekker, Inc. New York, pp. 139-196... [Pg.161]

Verma, R. K., Krishna, D. M., and Garg, S. (2002), Formulation aspects in the development of osmotically controlled oral drug delivery systems, I. Controlled Release, 79, 7-27. [Pg.1216]

Controlled Release Osmotic Drug Delivery Systems for Oral Applications... [Pg.424]

Osmotic-controlled drug release is described in detail in Chapter 4 (Section 4.6.1). Figure 6.12 illustrates the configuration of the Osmet pump for oral delivery, which resembles a rigid capsule in outer appearance and consists of ... [Pg.159]

Drug delivery systems of once-daily products (Concerta, Metadate CD, Ritalin LA, Adderall XR) provide 8 to 12 hours of symptom control. Concerta uses an oral osmotic (OROS) controlled-release delivery system, while other preparations use combinations of immediate-release or extended-release beads containing drug. Concerta is a nondeformable tablet and it should not be given to children with gastrointestinal narrowing due to the risk of obstruction. Older wax-matrix sustained-release products (e.g., Ritalin SR)... [Pg.1134]

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