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Osmotically-controlled release, oral drug

Controlled Release Osmotic Drug Delivery Systems for Oral Applications... [Pg.424]

This system is the only osmotic system developed commercially at this time that is suitable for the oral administration of insoluble drugs to humans. It has been utilized in the development of several other drugs including isradipine, doxazosin, diltiazem, contraceptive steroids, glipizide, and verapamil [48-53], The system has also been utilized to codeliver the free bases of compounds normally administered as water-soluble salts such as pseudoephedrine and bromo-pheniramine [54], The latter system includes both a loading dose and a controlled release dose and is intended for applications in the over-the-counter market. [Pg.448]

Osmotic-controlled drug release is described in detail in Chapter 4 (Section 4.6.1). Figure 6.12 illustrates the configuration of the Osmet pump for oral delivery, which resembles a rigid capsule in outer appearance and consists of ... [Pg.159]

Comparative pharmacokinetic profiles of nifedipine delivered from Procardia XL, an osmotic pressure-controlled drug delivery system, once-a-day versus that from Procardia, an immediate-release dosage form, taken on time 0, 8 and 16 in human volunteers. Modified from Y.W. Chien. Oral drug delivery and delivery systems. Y.W.Chien (ed.) (1992) Novel Drug Delivery Systems. Marcel Dekker, Inc. New York, pp. 139-196... [Pg.161]

Verma, R. K., Krishna, D. M., and Garg, S. (2002), Formulation aspects in the development of osmotically controlled oral drug delivery systems, I. Controlled Release, 79, 7-27. [Pg.1216]

Most of the oral sustained-release products are diffusional layer tablets coated with an insoluble polymer, such as a tablet with a biodegradable matrix or an osmotic controlled tablet. The mechanism involves the drug dissolved within the semipermeable polymeric coating. After water absorption, the tablet matrix generates an osmotic pressure, which drives the drug solution out through a tiny hole in the coated tablet. [Pg.185]

Drug delivery systems of once-daily products (Concerta, Metadate CD, Ritalin LA, Adderall XR) provide 8 to 12 hours of symptom control. Concerta uses an oral osmotic (OROS) controlled-release delivery system, while other preparations use combinations of immediate-release or extended-release beads containing drug. Concerta is a nondeformable tablet and it should not be given to children with gastrointestinal narrowing due to the risk of obstruction. Older wax-matrix sustained-release products (e.g., Ritalin SR)... [Pg.1134]

Waterman, K.C., Goeken, G.S., Konagurthu, S., Likar, M.D., MacDonald, B.C., Mahajan, N., Swaminathan, V., 2011. Osmotic capsules a universal oral, controlled-release drug de-hvery dosage form. Journal of Controlled Release 152, 264—269. [Pg.153]

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