Oral drug delivery controlled-release

As pharmaceutical scientists gain experience and tackle the primary challenges of developing stable parenteral formulations of proteins, the horizons continue to expand and novel delivery systems and alternative routes of administration are being sought. The interest in protein drug delivery is reflected by the wealth of literature that covers this topic [150-154]. Typically, protein therapeutics are prepared as sterile products for parenteral administration, but in the past several years, there has been increased interest in pulmonary, oral, transdermal, and controlled-release injectable formulations and many advances have been made. Some of the more promising recent developments are summarized in this section. 

E. Lipka and G. L. Amidon, Setting bioequivalence requirements for drug development based on preclinical data optimizing oral drug delivery systems, J. Controlled Release, 62, 41 (1999). 

LZ Benet, CY Wu, MF Hebert, VJ Wacher. Intestinal drug metabolism and antitransport processes A potential paradigm shift in oral drug delivery. J Controlled Release 39 139-143, 1996. 

A Gutowska, JS Bark, IC Kwon, YH Bae, Y Cha, SW Kim. Squeezing hydrogel for controlled oral drug delivery. J Controlled Release 48 141-148, 1997. 

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery, J. Controlled Release 1999, 62, 25-31. 

Lin YH, Sonaje K, Lin KM et al (2008) Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs. J Control Release 132 141-149... 

Bernkop-Schnurch, A., D. Guggi, and Y. Pinter. 2004. Thiolated chitosans development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system. J Control Release 94 177. 

Ahmed, A., C. Bonner, and T.A. Desai. 2002. Bioadhesive microdevices with multiple reservoirs a new platform for oral drug delivery. J Control Release 81 291. 

Ju, T., Cooper, A., Gauri, V., and Patel, M. pH controlled release oral drug delivery Effects of bulk and iternal pH. Paper no. PDD 7491, AAPS Annual Meeting, San Diego, CA, 1994. 

Comparative pharmacokinetic profiles of nifedipine delivered from Procardia XL, an osmotic pressure-controlled drug delivery system, once-a-day versus that from Procardia, an immediate-release dosage form, taken on time 0, 8 and 16 in human volunteers. Modified from Y.W. Chien. Oral drug delivery and delivery systems. Y.W.Chien (ed.) (1992) Novel Drug Delivery Systems. Marcel Dekker, Inc. New York, pp. 139-196... 

Sudhakar, Y., Kuotsu, K., and Bandyopadhyay, A. K. (2006), Buccal bioadhesive drug delivery—A promising option for orally less efficient drugs, J. Controlled Release, 114, 15 10. 

Verma, R. K., Krishna, D. M., and Garg, S. (2002), Formulation aspects in the development of osmotically controlled oral drug delivery systems, I. Controlled Release, 79, 7-27. 

Wiwattanapatapee, R. Jee, R.D. Duncan, R. PAMAM dendrimers as a potential oral drug delivery system dendrimer complexes with piroxicam. Proc. Int. Symp. Control. Release Bioact. Mater. 1999, 26, 145-146. 

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