Anticancer drugs, controlled release

Bontha, S., et al. (2006), Polymer micelles with cross-linked ionic cores for delivery of anticancer drugs,/. Controlled Release, 114(2), 163-174. 

Collagen/ HEMA mixed with collagen and anticancer drugs Controlled release of Jeyanthi and Rao, 1990... 

HPMA conjugates of other anticancer drugs such as paclitaxel, camptothecin, and platinates were synthesized and evaluated in both animals and humans. Controlled drug release at the tumor sites was a major challenge for these systems. 

Narayani, R. Rao, K.P. Gelatin microsphere cocktails of different sizes for the controlled release of anticancer drugs. Int. J. Pharm. 1996, 143, 255-258. 

Figure 6 In vitro and in vivo performance of an anticancer drug-loaded microchip delivery system (A) In vitro release of BCNU into phosphate buffer pH 7.2. The reservoirs contained either pure BCNU or binary BCNU PEG blends. The dashed lines indicate the time points of device activation (opening 50% of the reservoirs). (B) Evolution of the tumor size in rat flanks upon SC implantation of BCNU PEG-loaded microchips, containing 0.67, 1.2, or 2.0 mg drug and being activated 11 and 16 days post tumor implantation (50% of the reservoirs being opened at each time), or upon SC injection of die same amounts of BCNU and PEG, or upon SC implantation of a microchip containing 2 mg BCNU, but which was not activated. For reasons of comparison, also a nontreated control group is included. Source From Ref. 49.

Initially, the ability to incorporate biomolecules during the growth of conducting polymers and to expel these molecules by electrical stimulation was seen as a means to develop novel controlled-release systems79-80 for active ingredients such as anticancer drugs (flouracil)81 or anti-inflammatories (dexamethasone).82... 

Figure 9.17 Release of anticancer drugs from poly(HEMAF-collagen hydrogels. Controlled release of 5-fluorouracil 130), mitomycin C (M, 334), and bleomycin Ml 1,417) into phosphate-buffered water at 37 °C from p(HEMA) polymerized in the presence of drug and 5% eoUagen. The hydrogels were hydrated ( 40% water) throughout the experiment. Adapted from [57].

Figure 9.22 Release of chemotherapy drugs from polyanhydride matrices. Release of anticancer drugs from a pCPP/SA polyanhydride matrix, (a) BCNU, (b) 4-hydroxy-cyclophosphamide, and (c) paclitaxel. The insets in panels (a) and (b) show diffusion-controlled release (i.e., the percentage released is proportional with respect to the square root of time) is 7 x 10 and 3 x 10 ° cm /s, respectively. Data from [77].

Jeyanthi, R. and K. Rao, Controlled release of anticancer drugs from collagen-poly(hema) hydrogel matrices. Journal of Controlled Release, 1990, 13, 91-98. 

Figure 10.5 Controlled release of anticancer compounds from polymeric matrices, (a) Release of cisplatin (circles) from p(FAD/SA) initially containing 10% drug. Similar results have been obtained for BCNU, MTX, and a variety of other compounds (see [18, 19] for details), (b) Release of BCNU from EVAc (circles), p(CPP/ SA) (squares), and p(FAD/SA) (triangles) matrices initially containing 20% drug.

Parida U.K., Nayak A.K., Binhani B.K., Nayak P.L. S)mthesis and characterization of chitosan-polyvinyl alcohol blended with cloisite 30B for controlled release of the anticancer drug curcumin. Journal of Biomaterials and Nanobiotechnology. 2011 2 414-425. 

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