Amphiphilic drug release control

Kim, S. Y., I. G. Shin, Y. M. Lee, C. S. Cho, and Y. K. Sung. 1998. Methoxy polyethylene glycol) -and caprolactone amphiphilic block copolymeric micelle containing indomethacin. II. Micelle formation and drug release behaviorfe.Control. Rel.51 13-22. 

Matson JB, Newcomb CJ, Bitton R, Stupp SI (2012) Nanostructure-templated control of drug release from peptide amphiphile nanofiber gels. Soft Matter 8 3586-3595... 

There are a number of liquid crystalline phases formed by amphiphilic molecules, notably surfactants, polar lipids and block copolymers, including discrete and bicontinuous cubic phases, hexagonal phases (and their reversed counterparts), lamellar phases, intermediate phases, etc. A number of these phases are interesting from a drug delivery point of view. This is due to the frequently large solubilization capacity of both hydrophilic and hydrophobic substances, possibilities to control the drug release rate, favourable rheological properties, suitable water transport rates, excellent stability, etc. 

Liquid crystalline phases are also of interest from the point of view of controlled or sustained release, or even the absence (e.g. in the case of certain potent enzymes) of such release of bioactive molecules. For example, due to the presence of both water and oil channels in bicontinuous cubic structures, such systems are capable of solubilizing both hydrophilic, hydrophobic and amphiphilic drugs, the release of which can be sustained over extended periods of time. Particularly interesting in this respect is the incorporation of large oligopeptide or macromolecular drugs (e.g. enzymes). For example, Ericsson et al. investigated the incorporation of lysozyme in a cubic phase formed by monoolein and water, and found that a considerable amount could be solubilized in the liquid crystalline phase (182). Furthermore, the incorporation of c -lactalbumin, bovine serum albumin and pepsin was found to resemble that... 

Polymeric micelle systems (PMS) are made by the self-assembly of amphiphilic block copolymers in an aqueous enviromnent. The important features of PMS are drug solubilization, controlled drug release, and drug targeting [26]. This chapter focuses and discusses the current scenario of natural biodegradable polymeric-based nanoblends for protein and gene delivery with a special emphasis on the pharmaceutical and biomedical approaches. 

Mei, X. Yang, S. Chen, D. Li, N. Li, H. Xu, Q. Ge, J. Lu, J. Light-triggered reversible assemblies of azobenzene-containing amphiphilic copolymer witb beta-cyclodexlrin-modifled hollow mesoporous silica nanoparticles for controlled drug release. Chem. Commun. 2012, 48, 10010-100102. 

Yuan W, Li X, Gu S, Cao A, Ren J. Amphiphilic chitosan graft copolymer via combination of ROP, ATRP and click chemistry synthesis, self-assembly, thermosensitivity, fluorescence, and controlled drug release. Polymer. 2011 52 658-66. 

In order to examine the drug release property of the polyrotaxane micelle system, amphotericin B (AmB) was selected as a model dmg to evaluate the potential of the resulting amphiphilic PR-containing triblock copolymers as carriers for the controlled release. AmB is a broad-spectmm chemotherapy and organ antifungal therapy for the treatment of systemic transplantation, but an ahphatic water-insoluble... 

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