Controlled drug release advantages

Most of the drug delivery systems that have been studied for clinical application are capable of rate- and/or time-controlled drug release. The therapeutic advantages in these approaches lie in the in vivo predictability of release rate, minimized peak plasma levels, predictable and extended duration of action and reduced inconvenience of frequent re-dosing and hence, improved patient compliance [1]. 

Grafted chitosans have great utility in controlled drug release [115], tissue engineering [116], wound-healing [117] and cardiovascular applications [118-119]. Moreover, there are several reports regarding the use of enzymes in polymer s)m-thesis and modification [120-121]. In fact, enz)mies offer the potential advantage... 

The use of biodegradable polymeric systems for tumor immunotherapy has received limited study as compared with more conventional cell-based approaches.However, the advantage for tumor immunotherapy lies in the diversity of materials already generated from years of research in the suture industry and more recently from the area of controlled drug release. 

Controlled drug release formulations offer several advantages over conventional dosage forms (Fig. 2). Some of the salient features of controlled release formulations are described below. 

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