Drug-delivery systems, polymer

SH Gehrke, JF McBride, SM O Connor, H Zhu, JP Fisher. Gel-coated catheters as drug delivery systems. Polym Mat Sci Eng 76 234-235, 1997. 

Licciardi M, Giammona G, Du J, Armes SP, Tang Y, Lewis AL. New folate-functionalized biocompatible block copolymer micelles as potential anti-cancer drug delivery systems. Polymer 2006 47 2946-2955. 

Simo, C., Cifuentes. A., Gallardo, A. (2003). Drug delivery systems Polymers and drugs monitored by capillary electromigration methods., mj21flJgfl 797(1-2), 37-49. 

CHO Choi, C., Chae, S.Y., and Nah, J.-W., Thermosensitive poly(V-isopropylaciylamide)-i-poly(e-caprolactone) nanoparticles for efficient drug delivery system. Polymer, 47, 4571, 2006. 

Changyraig C, Chae SY, Jae-Won N (2006) Thermosensitive poly(nisopropylacrylamide)-b-poly(e-caprolactiHie) nanopartieles for efficient drug delivery system. Polymer 47 4571... 

Goldbart, R. Traitel, T. Lapidot, S. A. Kost, J. Enzymatically controlled responsive drug delivery systems. Polym. Adv. Techtwl. 2002,13,1006-1018. 

M.EA. Taleb, Radiation synthesis of polyampholytic and reversible pH-responsive hydrogel and its apphcation as drug delivery system. Polymer Bulletin, 61 (3), 341-351,2008. 

H. Schmitt, N. Creton, K. Prashantha, J. Soulestin, M.R Lacrampe, and P. Krawczak, Melt-blended halloysite nanotubes/wheat starch nanocomposites as drug delivery system, Polym. Eng. Sci., 55, 573-580,2015. 

To enhance the desirable properties of biodegradable polymers, it is essential to understand the factors affecting their degradation and control them in order to design a more efficient drug delivery system. Polymer composition, surface properties, crystallinity, etc., are important factors affecting biopolymer degradation properties, in terms of rate and kinetics. 

N. Kuno, and S. Fujii, Recent advances in ocular drug delivery systems. Polymers, 3, 193-221,2011. 

Wu XS, Hoffman AS, Yager P. Conjugation of phosphatidylethanolamine to poly(N-isoropylacrylamide) for potential use m liposome drug delivery system. Polymer 1992 33 4659-4662. 

Fiebrig I (1995) Solution Studies on the Mucoadhesive Potential of Various Polymers for use in Gastrointestinal Drug Delivery Systems. PhD Thesis, University of Nottingham, Nottingham, UK... 

Microelectronic circuits for communications. Controlled permeability films for drug delivery systems. Protein-specific sensors for the monitoring of biochemical processes. Catalysts for the production of fuels and chemicals. Optical coatings for window glass. Electrodes for batteries and fuel cells. Corrosion-resistant coatings for the protection of metals and ceramics. Surface active agents, or surfactants, for use in tertiary oil recovery and the production of polymers, paper, textiles, agricultural chemicals, and cement. 

Phosphazene polymers can act as biomaterials in several different ways [401, 402,407]. What is important in the consideration of skeletal properties is that the -P=N- backbone can be considered as an extremely stable substrate when fluorinated alcohols [399,457] or phenoxy [172] substituents are used in the substitution process of the chlorine atoms of (NPCl2)n> but it becomes highly hydrolytically unstable when simple amino acid [464] or imidazole [405-407] derivatives are attached to the phosphorus. In this case, an extraordinary demolition reaction of the polymer chain takes place under mild hydrolytic conditions transforming skeletal nitrogen and phosphorus into ammonium salts and phosphates, respectively [405-407,464]. This opens wide perspectives in biomedical sciences for the utilization of these materials, for instance, as drug delivery systems [213,401,405,406,464] and bioerodible substrates [403,404]. 

Poly[(4-carboxylatophenoxy)(methoxyethoxyethoxy)phosphazene] copolymers of variable compositions were synthesized by Allcock [645] in 1996. These polymers were found to be soluble in alkaline solutions. When crosslinked (by y-rays or by addition of CaCl2 to the polymer solution) the resulting hydrogels were found able to contract or expand as a function of the pH of the solution and their utilization as pH-responsive materials for drug delivery systems could be envisaged. 

Skeletal Biocompatibility. Two Substituent Groups Attached to the Same Phosphazene Skeleton. Hydrolytical Instability 0 II — NH- CH2— C- OC2H5 Glycine or Lower Alkyl Aminoacid Esters Hydrolytically Unstable Polymers. Bioerodible Materials. Drug Delivery Systems. Tissue Engineering... 

These discoveries generated a lot of effort over the successive 25 years in the preparation of especially designed drug delivery systems for the controlled release of radioactive progesterone [654], colchicine [656], naproxen [657,673, 674], mitomycin C [675-677], inulin [678], trimethoprin [657], succinylsul-fathiazole [657], ethacrynic acid [653], and steroids [633], regardless of whether these drugs are physically trapped in polyphosphazene matrices, or chemically bonded to the polymer skeleton. 

AUcock HR (1990) In Chasin M, hanger R (eds) Biodegradable polymers as drug delivery systems. Dekker, New York, chap 5, p 163... 

Pitt, C. G., and Schindler, A., The design of controlled drug delivery systems based on biodegradable polymers, in Biodegradable and Delivery Systems for Contraception, Progress in Contraceptive Delivery Systems, Vol. 1 (E. S. E. Hafez and W. A. A. van Os, eds.), MTP Press Ltd., Lancaster, England, 1980, pp. 17-46. 

One useful drug delivery system is derived from polymers that contain acid-labile linkages in their backbones because hydrolysis rates of such polymers can be readily manipulated by means of acidic or basic excipients physically incorporated into the matrix (2). Further, under certain conditions the hydrolysis of such polymers can be... 

These results open the exciting possibility of using degradable, tyrosine-derived polymers as "custom-designed" antigen delivery devices. On the other hand, our results indicate that the immunological properties of tyrosine-derived polymers will have to be carefully evaluated before such polymers can be considered for use as drug delivery systems or medical implants. 

YoUes, S., and Sartori, M. F., Degradable polymers for sustained drug release, in Drug Delivery Systems (R. L. Juliano, ed.), Oxford University Press, New York, 1980, pp. 84-111. 

Since the purpose of this book is to describe applications of biodegradable polymers to drug delivery systems, particularly from the perspective of the materials employed, the approach taken in this chapter has been to focus on the natural biodegradable polymers which have been used most extensively as matrices for the delivery of drugs. Consideration was also given to the fact that collagen has not been the subject of any recent reviews. 

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