Gastrointestinal Drug Delivery

Doshi and Tank formulated dummy tablets of gellan using the wet granulation fabrication technique and discovered their feasibility as gastro-retentive tablets [88]. 

Gellan-chitosan polyelectrolyte complex beads, prepared by solution extruding method, have been explored for their potential application in delivery of metronidazole and metronidazole benzoate to the gastrointestinal tract [89]. 

Foda and Ali summarized the potential applications of gellan as gastro-retentive drug delivery systems for enhancing the efficiency of antibiotics [32]. 

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Fiebrig I (1995) Solution Studies on the Mucoadhesive Potential of Various Polymers for use in Gastrointestinal Drug Delivery Systems. PhD Thesis, University of Nottingham, Nottingham, UK... 

A. H. Staib, B. G. Woodcock, D. Loew, and O. Schuster, Chapter 8 Remote control of gastrointestinal drug delivery in man (L. F. Prescott, and W. S. Nimmo, eds.), Novel Drug Delivery and 1st Therapeutic Application, J. Wiley Sons, Chichester, UK, 1989, pp. 79-88. 

Freund, O. (2001), Biodistribution and gastrointestinal drug delivery of new lipidic multilamellar vesicles, Drug Deliv., 8,239-244. 

Lerner, I.E. Flashner, M. Penhasi, A. Delayed Total Release Gastrointestinal Drug Delivery System. WO Patent 99/18938, 1999. 

With a background in pharmaceutical technology and biopharmaceutics, Catherine Tuleu s leading theme of research is on formulation for gastrointestinal drug delivery with emphasis on colonic targeting, where she developed expertise in in vitro, and animal and clinical... 

Thimma RT, Tammishetti S. Barium chloride cross-linked carboxymethyl guar gum beads for gastrointestinal drug delivery. J Appl Polym Sci. 2001 82 3084-90. 

A number of the water-soluble polymers also have adhesive properties which are being extensively evaluated for drug delivery (9). These polymers will adhere to the mucous coating in the gastrointestinal tract, the nose, and the mouth to delay passage and sustain drug release. Those polymers with the best adhesive properties are those with hydroxyl and carboxyl groups. Table II lists some of the bioadhesive polymers and their adhesive properties. 

MF Williams, GF Dukes, W Heizer, Y-H Han, DJ Hermann, T Lampkin, LJ Hak. Influence of gastrointestinal site of drug delivery on the absorption characteristics of ranitidine. Pharmaceut Res 9 1190-1194, 1992. 

Ho NFH, JY Park, PF Ni, WI Higuchi. (1983). Advancing quantitative and mechanistic approaches in interfacing gastrointestinal drug absorption studies in animals and man. In WG Crouthamel, A Sarapu, eds. Animal Models for Oral Drug Delivery in Man In Situ and In Vivo Approaches. Washington, DC APh/APS, pp 27-106. 

In the gastrointestinal tract, a mucoadhesive drug delivery system provides advantages in prolonging the residence time of devices. The use of pH-sensitive bioadhesive polymers has been proposed [26], An extensive review of pH-sensi-tive hydrogels is given by Brpndsted and Kopecek [27],... 

PK Gupta, S-H Leung, JR Robinson. Bioadhesive/mucoadhesives in drug delivery to the gastrointestinal tract. In V Lenaerts, R Gurny, eds. Bioadhesive Drug Delivery Systems. Boca Raton, FL CRC Press, 1990, pp 65-92. 

This model consists of a total of five compartments, the drug delivery system (DDS), the gastrointestinal tract (GIT), the central compartment (Central), and two elimination compartments denoted with a dashed box outline, one for pre-systemic elimination (Unavailable) and one for... 

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