Macromolecular drugs polymer-controlled drug-delivery system

Weiner, A.L. Cannon, J.B. Tyle, P. Commercial approaches to the delivery of macromolecular drugs with liposomes. In Controlled Release of Drugs Polymers and Aggregate Systems Rosoff, M., Ed. VCH Publishers New York, 1989 217-253. 

Despite increasing advances in the use of controlled release polymeric delivery systems (1-6). it has, in general, proved difficult to develop such vehicles for the long-term administration of macromolecular drugs. This is largely due to the fact that most blocompatlble polymers such as silicone rubber are impermeable to molecules over 600 molecular weight (7). Recent studies in our laboratory have demonstrated, however, that solvent casting of a variety of polymeric materials (ethylene-vinyl acetate... 

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