Responsive drug delivery

Calcium-responsive drug delivery, 9 64-65 Calcium salt(s)... 

Infection-responsive drug delivery, 9 63 Infections, sulfonamides for, 23 499 Infectious Bursal Disease Virus (IBDV) vaccine, from yeast, 26 487-488 Infectious diseases... 

Inflammation, as a toxic effect, 25 204-205 Inflammation-responsive drug delivery, 9 63... 

Chung, J. E., Yokoyama, M., Yamato, M., Aoyagi, T., Sakurai Y., and Okano, T. Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(A-isopropylacrylamide) and poly(butylmethacrylate), J. Contr. Rel, 1999, 62, 115-127. 

Murdan, S. Electro-responsive drug delivery from hydrogels. J. Contr. Rel. 92 1—17, 2003. 

Poly(N-isopropylacrylamide) Hydrogels for Thermo-Responsive Drug Delivery... 

The gastrointestinal tract is known to possess a wide pH range, from a gastric pH of 1-2 to an intestinal tract pH of 7-8. Such significant changes could be utilized for the formation of pH-responsive drug delivery devices. Additionally, tumor sites and some sites of infection are known to have local acidic pH values amenable to pH-sensitive release methods. 

O and N carboxy methyl CS Reductive alkylation Direct alkylation Formation of an amphoteric polymer which extends the range of pH, enhancing CS solubility in different solvents Modified drug delivery pH responsive drug delivery DNA delivery Targeted drug delivery Permeation enhancer Cosmetics... 

Apart from the already established formulations, researchers are trying to develop novel oil-based formulations to combat the poor solubility and bioavailablity of NCE. Shevachman et al. developed novel U-type microemulsions to improve the percutaneous permeability of diclofenac. Shah et al.2 2 used microwave heating for the preparation of solid lipid nanoparticles by microemulsion techniques, which resulted in improved particle characteristics. Ki et al. reported sustained-release liquid crystal of injectable leuprolide using sorbitan monooleate. Recently, various novel oil-based drug delivery technologies are reported, which includes tocol emulsions, solid lipid nanopar-ticles, nanosuspensions, Upid microbubbles, sterically stabilized phospholipid micelles, and environmentally responsive drug delivery systems for parenteral administration.25 259... 

P. Gupta, V. Kavita, G. Sanjay, Hydrogels from controlled release to pH-responsive drug delivery. Drug Discovery Today 7. 569-579 (2002)... 

Goldbart, R. Traitel, T. Lapidot, S. A. Kost, J. Enzymatically controlled responsive drug delivery systems. Polym. Adv. Techtwl. 2002,13,1006-1018. 

Popat, A. Liu, J. Lu, G. Q. Qiao, S. Z. A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles. J. Mater. Chem. 2012, 22, 11173— 11178. 

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