Controlled drug delivery systems

Liquid crystalline, ferroelectric, and photochromic systems Controlled drug-delivery from polyphosphazenes Use in bone tissue engineering... 

Those anaiytioai systems where liposomes are used as artificial cell membranes to study body distribution mechanisms as efficient drug-delivery systems, controlled drug delivery, the synthesis of new biomaterial for tissue engineering and gene therapy are worthy of special mention. 

K. Heihnaim, Therapeutic Systems Rate-Controlled Drug Delivery, Concept and Development, 2nd rev. ed., Thieme-Stratton, Inc., New York, 1984, pp. 66-82. 

Pitt, C. G., and Schindler, A., The design of controlled drug delivery systems based on biodegradable polymers, in Biodegradable and Delivery Systems for Contraception, Progress in Contraceptive Delivery Systems, Vol. 1 (E. S. E. Hafez and W. A. A. van Os, eds.), MTP Press Ltd., Lancaster, England, 1980, pp. 17-46. 

Welling, P.G. Deobrinska, M.R. "Dosing considerations and bioavailability assessment of controlled drug delivery systems" In Controlled Drug Delivery Robinson, J.R., Lee, V.H.L., Eds. Drugs and the Pharmaceutical Sciences M. Dekker, New York, NY, 1987, Vol. 29, pp. 253-292. 

Biodegradable polyurethanes have been proposed and studied before (9-72). The difference in our study is the inclusion of a phosphoester linkage instead of the commonly used polyester component. This seems to provide more flexibility as the side chain of the phosphate or phosphonate can be varied. For controlled drug delivery applications, drugs can be linked to this site to form a pendant delivery system. Moreover, for certain medical applications, fast degradation rate is obtainable by the introduction of these hydrolyzable phosphoester bonds. With the LDI based polyurethanes, drugs or other compounds of interest can also be coupled to the ester side chain of the lysine portion. 

J. Kopecek and R. Duncan, Poly(/V-(2-hydro-xypropyl)methacrylamide) macromolecules as drug carrier systems, in Polymers in Controlled Drug Delivery (L. Ilium and S. S. Davis, eds.), Wright, Bristol, 1987, p. 152. 

K Tojo, Y Sun, M Ghannam, Y Chien. Characterization of a membrane permeation system for controlled drug delivery studies. AIChE J 31 741, 1985. 

K Sawahata, M Hara, H Yasunaga, Y Osada. Electrically controlled drug delivery system using polyelectrolyte gels. J Controlled Release 14 253-262, 1990. 

Controlled drug delivery, membrane technology in, 15 847-848 Controlled drug release formulations (CDRFs), 9 51, 55 polymers in, 9 71-73 Controlled drug release systems, 9 50-51 design, 9 51-52 development, 9 55-57 intelligent, 9 56-57 in market, 9 83—85... 

Dissolution, of viscose, 11 254-255 Dissolution-controlled drug delivery, degradation/ erosion-based drug delivery systems, 9 11-19 Dissolution inhibition, by... 

Membrane separators, 23 795-796 Membrane/sonication/wet oxidation (MEMSONIWO) systems in wastewater treatment, 25 911-912 Membrane systems, as advanced wastewater treatment, 25 909 Membrane technology, 25 796-852 applications for, 25 824-848 in controlled drug delivery,... 

Popovic N, Brundin P (2006) Ther eutic potential of controlled drug delivery systems in neurodegen-erative diseases. Int J Pharm 314 120—126... 

The amphiphilic nature of the polyester/PHEMA networks provides gels able to swell in both organic and aqueous media, which prompted us to study them as controlled drug delivery systems [114]. The most valuable characteristic feature of these amphiphilic networks is their potential to sustain the drug delivery... 

The relatively constant transit time in the small intestine of approximately 3-4 h is another physiological characteristic which can be exploited to achieve colon specificity (time-controlled drug release). After gastric empt5ung, a time-controlled drug delivery system is intended to release the drug after a predetermined lag phase. 

Figure 6.4. Swelling-induced time-controlled drug delivery systems.

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