Drug delivery biodegradable polymer systems

Leong, K. Synthetic biodegradable polymer drug delivery systems, in Polymer for Controlled Drug Delivery, ed. P. Tarcha. Boca Raton FL CRC Press, 1991, pp. 127-148. 

Over the past few years, considerable attention has been devoted to the development of biodegradable, injectable polymer drug-delivery systems [60]. This can be attributed to the... 

AUcock HR (1990) In Chasin M, hanger R (eds) Biodegradable polymers as drug delivery systems. Dekker, New York, chap 5, p 163... 

Pitt, C. G., and Schindler, A., The design of controlled drug delivery systems based on biodegradable polymers, in Biodegradable and Delivery Systems for Contraception, Progress in Contraceptive Delivery Systems, Vol. 1 (E. S. E. Hafez and W. A. A. van Os, eds.), MTP Press Ltd., Lancaster, England, 1980, pp. 17-46. 

Since the purpose of this book is to describe applications of biodegradable polymers to drug delivery systems, particularly from the perspective of the materials employed, the approach taken in this chapter has been to focus on the natural biodegradable polymers which have been used most extensively as matrices for the delivery of drugs. Consideration was also given to the fact that collagen has not been the subject of any recent reviews. 

Kohn, J. In Biodegradable Polymers as Drug Delivery Systems Chasin M. Langer, R., Eds. Drugs and the Pharmaceutical Sciences Marcel Dekker, Inc., New York, NY, 1990, Vol. 45, pp. 195-229. 

Biodegradable Polymers as Drug Delivery Systems, edited by Mark Chasin and Robert Langer... 

F Lescure, D Bichon, JM Anderson, E Doelker, ML Pelaprat, RJ Gurny. Acute histopathological response to a new biodegradable polypeptidic polymer for implantable drug delivery system. Biomed Mater Res 23 1299-1313, 1989. 

Poly-j3-malate is readily degraded completely to L-malic acid under both acid and base conditions [108], and it can also be hydrolyzed by enzymes within the cell [105,106]. Recently, several bacteria were isolated which were able to utilize poly-/i-malate as sole carbon source for growth [109]. Because the polymer is biodegradable and bioadsorbable, it is of considerable interest for pharmaceutical applications, especially in controlled-release drug delivery systems [97,98]. Chemical routes to poly-/ -malate are expected to provide materials with various properties [110]. 

Recently, biodegradable polymers have been used to fabricate macro- and nanometer scale self-assembled systems such as microspheres (MSs), nanospheres (NSs), polymer micelles, nanogels, and polymersomes (Fig. 1). These have attracted growing interest because of their potential utility for drug delivery systems (DDS), tissue engineering, and other applications. To construct these self-assembled systems... 

Jeong B, Choi YK, Bae YH et al (1999) New biodegradable polymers for injectable drug delivery systems. J Control Release 62 109-114... 

Synthesis of aminopolysaccharides, therefore, is one of the important research areas in the field of functional materials, examples of biorelated polymers, antibacterial substance, and biodegradable polymers as well as materials for drugs and matrices of drug delivery systems. Only a few methods, however, such as ring-opening polymerization and enzymatic polymerization have been available for the precision synthesis of aminopolysaccharides [4,5],... 

---