Drug monitoring

Note When this reagent sequence is combined with the in situ measurement of the UV spectra of the chromatogram zones before derivatization this reagent sequence becomes virtually specific for hydrochlorothiazide and its related derivatives in the analysis of urine. Hence, it is possible to use it for drug monitoring and doping control. 

Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography, edited by Steven H. Y. Wong... 

TABLE 5-5. Therapeutic Drug Monitoring for Adverse Effects of Pharmacotherapy for Acute Coronary Syndromes... 

Develop a therapeutic drug-monitoring plan to assess both the effectiveness and the adverse... 

The most commonly used corticosteroids are methylpred-nisolone (IV and oral) and prednisone (oral), although prednisolone and dexamethasone also have been shown to be effective for organ transplantation. Corticosteroid doses vary by center-specific protocols, organ type, and patient characteristics. A typical taper would include an IV 100 to 500 mg bolus of methylprednisolone at the time of transplant and then a taper over 5 to 7 days to a maintenance dose of prednisone 20 mg/day or complete cessation.2,7 It is important for practitioners to know that approximately 4 mg methylprednisolone is equivalent to 5 mg prednisone and 0.75 mg dexamethasone.11 At most transplant centers, therapeutic drug monitoring of corticosteroids is not employed. Corticosteroids are associated with a variety of acute and chronic toxicides. The most common adverse events have been summarized in Table 52-5. 

Select patients for whom therapeutic drug monitoring may be valuable. 

Therapeutic drug monitoring (TDM) or applied pharmacokinetics is the use of serum drug concentrations to optimize therapy.28,36,37 Non-AIDS patients with drug-susceptible TB... 

Based on the information provided, which clinical and laboratory parameters should be monitored in this patient to determine efficacy and avoid toxicity Is this patient a can-didate for therapeutic drug monitoring Why or why not ... 

Peloquin CA. Therapeutic drug monitoring in the treatment of tuberculosis. Drugs 2002 62 2169-2183. 

Therapeutic drug monitoring The process of using drug concentrations, pharmacokinetic principles, and pharmacodynamic criteria to optimize drug therapy in individual patients. 

Y Tanigawara. Role of p-glycoprotein in drug disposition. Ther Drug Monitor 22 137-140, 2000. 

M Mayersohn. Special pharmacokinetic considerations in the elderly. In WE Evans, JJ Schentag, WJ Jusko, eds. Applied Pharmacokinetics Principles of Therapeutic Drug Monitoring. 3rd ed. Vancouver, WA Applied Therapeutics, 1992, pp. 9-1-9-43. 

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