Insulin dependent diabetes

Blood sugar (blood glucose) in human beings is controlled by the secretion of (—>) insulin by the beta (B- or (3-) cells of the islands of Langerhans in the pancreas. Loss of insulin synthesis leads to (—>) diabetes. Type 1 diabetes (insulin dependent diabetes mellitus, EDDM) begins in juveniles as an organ-specific autoimmune reaction, the destructive insulitis. 

There are two types of diabetes, insulin-dependent and non-insulin-dependent. Between 90-95% of the estimated 13-14 million people in the United States with diabetes have non-insulin-dependent, or Type II, diabetes. Because this form of diabetes usually begins in adults over the age of 40 and is most common after the age of 55, it used to be called adult-onset diabetes. Its symptoms often develop gradually and are hard to identify at first therefore, nearly half of all people with diabetes do not know they have it. For instance, someone who has developed Type II diabetes may feel tired or ill without knowing why. This can be particularly dangerous because untreated... 

Therapy for insulin-dependent diabetes mellitus is usually achieved by daily subcutaneous injections of insulin, and insulin-mimetics which can be orally administered may be useful for the treatment of type I diabetes (insulin dependent) if suitable complexes of low toxicity can be identified (510, 511). 

Diabetes mellitus is a very common metabolic disease that is caused by absolute or relative insulin deficiency. The lack of this peptide hormone (see p. 76) mainly affects carbohydrate and lipid metabolism. Diabetes mellitus occurs in two forms. In type 1 diabetes (insulin-dependent diabetes mellitus, IDDM), the insulin-forming cells are destroyed in young individuals by an autoimmune reaction. The less severe type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM) usually has its first onset in elderly individuals. The causes have not yet been explained in detail in this type. 

Diabetes - insulin dependent Methyl malonic, propionic or isovaleric acidaemias Pyruvate carboxylase and multiple carboxylase deficiency Gluconeogenesis enzyme deficiency glucose-6-phosphatase, fructose-1,6-diphosphatase or abnormality of glycogen synthesis (glycogen synthase) Ketolysis defects Succinyl coenzyme A 3-keto acid transferase ACAC coenzyme A thiolase... 

A. Type I diabetes (insulin-dependent diabetes mellitus, IDDM)... 

An effect of diabetes. Insulin-dependent diabetes is often accompanied by hypertriglyceridemia, which is an excess blood level of triacylglycerides in the form of very low density lipoproteins. Suggest a biochemical explanation. 

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. Two principal forms of diabetes exist type 1 diabetes (insulin-dependent diabetes mellitus) and type 2 diabetes (noninsulin-dependent diabetes mellitus). Type 1 diabetes also... 

Type I diabetes (insulin-dependent diabetes mellitus, IDDM) is due to a failure to secrete insulin as a result of damage to the (3-cells of the pancreatic islets resulting from viral infection or autoimmune disease. There is also a genetic susceptibility the concordance of IDDM in monozygotic (identical) twins is about 50%. IDDM... 

There are multiple causes of diabetes. Whereas the molecular bases of some forms of diabetes are well understood, in many cases etiologies are unknown. It is customary to divide diabetes into two main forms insulin-dependent diabetes mellitus (IDDM), also referred to as Type I or juvenile-onset diabetes, and noninsulin-dependent diabetes mellitus (NIDDM), also called Type II or maturity-onset diabetes (3). 

In 1986, the FDA s Sugars Task Force assessed the impact of sugar consumption on human health and nutrition and concluded that sucrose is not an independent risk factor for heart disease, nor does it cause or contribute to the development of diabetes (62). Although diet is important after the onset of diabetes, sucrose can be well tolerated by insulin-dependent diabetics (63—65). 

Early applications of crystalline fructose focused on foods for special dietary applications, primarily calorie reduction and diabetes control. The latter application sought to capitalize on a signiftcandy lower serum glucose level and insulin response in subjects with noninsulin-dependent diabetes melUtus (21,22) and insulin-dependent diabetes (23). However, because fmctose is a nutritive sweetener and because dietary fmctose conversion to glucose in the hver requires insulin in the same way as dietary glucose or sucrose, recommendations for its use are the same as for other nutritive sugars (24). Review of the health effects of dietary fmctose is available (25). 

MODY is a type of non-insulin-dependent diabetes mellitus caused by rare autosomal-dominant mutations. Presently there are six known forms of the disease which are all due to ineffective insulin production or... 

Meglitinide contains a benzamide group. Meglitinide-related compounds such as nateglinide are non-sulfonylurea oral hypoglycemic drugs used in the treatment of type 2 (non-insulin dependent) diabetes mellitus. 

First trials with CD3 antibodies for therapy of autoimmune diseases (insulin-dependent diabetes mellitus psoriatic arthritis... 

Type 2 diabetes adjunct to insulin therapy in the stabilization of certain cases of insulin-dependent diabetes (type 1)... 

MARSHALL J A, HAMMAN R F and BAXTER J (1991) High-fat, low-carbohydrate diet and the etiology of non-insulin-dependent diabetes mellitus the San Luis Valley diabetes study. J Epidemiol. 134 (6) 590-603. 

SALMERON J, MANSON J E, STAMPFER M J, COLDITZ G, WING A L and WILLET W C (1997b) Dietary fiber, glycemic load and risk of non-insulin-dependent diabetes mellitus in women. JAMA. 277 (6) 472-7. 

---