Coenzyme succinyl

Succinyl coenzyme A trisodium salt [108347-97-3] M 933.5. If it should be purified further then it should be dissolved in H2O (0.05g/mL) adjusted to pH 1 with 2M H2SO4 and extracted several times with Et20. Excess Et20 is removed from the aqueous layer by bubbling N2 through it and stored frozen at pH 1. When required the pH should be adjusted to 7 with dilute NaOH and used within 2 weeks (samples should be frozen). Succinyl coenzyme A is estimated by the hydroxamic acid method [J Biol Chem 242 3468 1967]. It is more stable in acidic than in neutral aqueous solutions. [Methods Enzymol 128 435 7956.]... 

Succinyl-coenzyme A H -COSR COOH L-Methylmalonyl coenzyme ... 

ALAD, and ferrochelatase. Lead indirectly stimulates the mitochondrial enzyme ALAS, which catalyzes the condensation of glycine and succinyl-coenzyme A to form ALA. The activity of ALAS is the rate-limiting step in heme biosynthesis increase of ALAS activity occurs through feedback derepression. Lead... 

Succinoglycans, 20 576-577 Succinonitrile, 8 174 Succinyl chloride, 23 420 Succinyl coenzyme A... 

Diabetes - insulin dependent Methyl malonic, propionic or isovaleric acidaemias Pyruvate carboxylase and multiple carboxylase deficiency Gluconeogenesis enzyme deficiency glucose-6-phosphatase, fructose-1,6-diphosphatase or abnormality of glycogen synthesis (glycogen synthase) Ketolysis defects Succinyl coenzyme A 3-keto acid transferase ACAC coenzyme A thiolase... 

Table 1.4.15 Data from a acid transferase deficiency patient affected with succinyl coenzyme A 3-oxo ... 

Succinyl coenzyme A 3-oxo acid transferase catalyses the transformation of ACAC into acetoacetyl coenzyme A in the mitochondria of extra-hepatic tissues. This enzyme defect may be suggested in cases of severe ketoacidosis often associated with neurologic dysfunction [16]. 

ALA and PBG are the precursors of porphyrin synthesis (Fig. 7.3.1). ALA is synthesized from glycine and succinyl-coenzyme A by ALAS. Two molecules of ALA are converted to PBG by the enzyme ALAD. 

Lahti CJ, d Oliveira CE, Johnson PJ (1992) 3-Succinyl-coenzyme-A synthetase from Trichomonas vaginalis is a soluble hydrogenosomal protein with an amino-terminal sequence that resembles mitochondrial presequences. J Bacteriol 174 6822-6830... 

The formation of succinyl coenzyme A from methylmalonyl coenzyme A, part of the metabolism of odd-chain fatty acids, cholesterol, and the amino acids valine, isoleucine, threonine, and methionine... 

Wedding, R.T., Norman, A.W., and Black, M.K., Detection of phosphohistidine in succinyl coenzyme A synthetase isolated from Jerusalem artichoke mitochondria, Plant Cell Physiol., 7, 707-710, 1966. 

In addition to succinate, malonate, fumarate, and phosphate, it has been reported in recent years that succinate dehydrogenase is activated by ATP, ITP, IDP (195), reduced ubiquinone-10 (195-197), succinyl coenzyme-A (198), formate, ClOr, I", Br-, C1 , NOa, SO4 ", acid pH... 

The precursor for vitamin B12 synthesis is uroporphyrinogen 111, the common precursor for aU porphyrins, including heme and chlorophyll. Uroporphyrinogen III is synthesized by condensation between succinyl coenzyme A (CoA) and glycine to yield 5-aminolevulinic acid. Two molecules of (5-amino-levulinic acid then condense to form the pyrrole phorphobilinogen, and four molecules of porphobilinogen condense to yield uroporphobilinogen III. 

Miller, W. W., and Richards, J. H., 1969, Mechanism of action of coenzyme B12. Hydrogen transfer in the isomerization of methylmalonyl coenzyme A to succinyl coenzyme A, J. Am. Chem. Soc. 91 1458nl507. 

Succinyl Coenzyme A Is Formed by the Oxidative Deearboxylation of a-Ketoglutarate... 

Succinyl Coenzyme A Is a Point of Entry for Several Nonpolar Amino Acids... 

Mammalian Porphyrins Are Synthesized from Glycine and Succinyl Coenzyme A... 

Mechanism Succinyl Coenzyme A Synthetase Transforms Types of Biochemical Energy... 

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