Diabetes mellitus non-insulin-dependent

MODY is a type of non-insulin-dependent diabetes mellitus caused by rare autosomal-dominant mutations. Presently there are six known forms of the disease which are all due to ineffective insulin production or... 

Meglitinide contains a benzamide group. Meglitinide-related compounds such as nateglinide are non-sulfonylurea oral hypoglycemic drugs used in the treatment of type 2 (non-insulin dependent) diabetes mellitus. 

MARSHALL J A, HAMMAN R F and BAXTER J (1991) High-fat, low-carbohydrate diet and the etiology of non-insulin-dependent diabetes mellitus the San Luis Valley diabetes study. J Epidemiol. 134 (6) 590-603. 

SALMERON J, MANSON J E, STAMPFER M J, COLDITZ G, WING A L and WILLET W C (1997b) Dietary fiber, glycemic load and risk of non-insulin-dependent diabetes mellitus in women. JAMA. 277 (6) 472-7. 

Non-insulin-dependent diabetes mellitus (NIDDM)-well controlled... 

NIDDM Non-insulin dependent diabetes mellitus PCR Polymerase chain reaction... 

The patient is taking glyburide for non-insulin-dependent diabetes mellitus and has been treated in the past for peptic ulcer disease with ranitidine and omeprazole. He has a history of allergy to various types of pollen but reports no allergies to drugs. He reports moderate consumption of alcohol and smoking 2 packs of cigarettes per day. 

Mutations in GK (Hx IV) causes maturity-onset diabetes of the young (MOD Y), a form of non-insulin-dependent diabetes mellitus (NIDDM) characterized by onset before 25 years of age and an autosomal dominant inheritance (PI 2). This suggests that the mutations in other forms of Hx may also contribute to the development of NIDDM. Among them, Hx II is a particularly attractive candidate, although this isozyme is not expressed in red blood cells. Hx II has been analyzed extensively in the muscle of prediabetic insulin-resistant individuals. But studies have shown that Hx II mutation alone is unlikely to have a significant role in the development of peripheral insulin resistance and NIDDM (L6). 

Frati AC, Jimenez E and Ariza CR. 1990b. Hypoglycemic effect of Opuntia ficus-indica in non-insulin dependent diabetes mellitus patients. Phytother Res 4 195—197. 

Diabetes mellitus is the most common cause of peripheral neuropathy in the United States. Approximately half of all diabetics demonstrate evidences of neuropathy. The usual clinical pattern is that of a slowly progressive, mixed sensorimotor and autonomic polyneuropathy. More acute, asymmetrical motor neuropathies are also seen, usually affecting the lumbosacral plexus, particularly in older persons with type 2 (non-insulin-dependent) diabetes mellitus. Patients with diabetes mellitus are also prone to develop isolated palsies of cranial nerve III or VII, and there is a high incidence of asymptomatic focal demyelin-ation in the distal median nerve. 

D8. Dean, J. D., Bishop, A., Morgan, R., Carolan, G., Owens, D. R., and Rees, A., Lipopro-tein(a) in non-insulin dependent diabetes mellitus. Diabetes Nutr. Metab. 5, 95-98 (1992). 

Ul. Umeda, F., Watanabe, J., Inouue, K., Hisatomi, A., Mimura, K., Yamauchi, T., Sako, Y., Kunisaki, M., Tajiri, Y., and Nawata, H., Effect of pravastatin on serum lipids, apolipopro-teins and lipoprotein (a) in patients with non-insulin dependent diabetes mellitus. Endocrinol. Jpn. 39, 45-50 (1992). 

Type 2 Peripheral tissue resistance to the action of insulin Insulin secretory defects Includes those formerly classified as adult onset diabetes, type II DM or non-insulin dependent diabetes mellitus (NIDDM). Ketosis is rare. 

NR, not reported TC, total cholesterol LDL-C, LDL cholesterol TG, triglycerides. Non-insulin-dependent diabetes mellitus. 

Gupta, R. R., Agrawal, C. G., Singh, G. P., and Ghatak, A. (1994). Lipid-lowering efficacy of psyllium hydrophilic mucilloid in non insulin dependent diabetes mellitus with hyperli-pidaemia. India J. Med. Res. 100, 237-241. 

Another form of diabetes is non-insulin-dependent diabetes mellitus (NIDDM, or adult diabetes, or type II diabetes). In this case, insulin is produced and a normal insulin level is detected in blood. But for various reasons its effect is reduced. This may be caused by a reduced number of insulin receptors on cells, or reduced effectiveness in binding to these receptors. The cause is complex and may involve genetic make-up, changes in lifestyle, nutritional habits, and environmental factors. 

Acetazolamide is a carbonic anhydrase inhibitor that reduces aqueous humour production and is therefore indicated in glaucoma to reduce the intraocular pressure. Salbutamol is a selective, short-acting beta2-agonist used as a bronchodilator in asthma. Tolbutamide is a short-acting sulphonylurea used in type 2 (non-insulin dependent) diabetes mellitus. Chlorpromazine is an aliphatic neuroleptic antipsychotic drug used in schizophrenia. Zafirlukast is a leukotriene-receptor antagonist that is indicated in the prophylaxis of asthma but should not be used to relieve acute severe asthma. 

Q43 non-insulin dependent diabetes mellitus Q44 continuous ambulatory peritoneal dialysis... 

Diabetes mellitus is a very common metabolic disease that is caused by absolute or relative insulin deficiency. The lack of this peptide hormone (see p. 76) mainly affects carbohydrate and lipid metabolism. Diabetes mellitus occurs in two forms. In type 1 diabetes (insulin-dependent diabetes mellitus, IDDM), the insulin-forming cells are destroyed in young individuals by an autoimmune reaction. The less severe type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM) usually has its first onset in elderly individuals. The causes have not yet been explained in detail in this type. 

As an adjunct to diet and exercise to lower the blood glucose in patients with type 2 (non-insulin-dependent) diabetes mellitus whose hyperglycemia cannot be controlled by diet and exercise alone. 

Diabetes mellitus has been traditionally classified into insulin-dependent diabetes mellitus (IDDM), also known as type I (formerly called juvenile-onset diabetes mellitus), and non-insulin-dependent diabetes mellitus (NIDDM), also known as type II (formerly referred to as adult-onset diabetes mellitus). There are clearly varying degrees of overlap, and though it is often important to know whether a particular individual possesses relative insulin deficiency or relative insulin resistance or both, some of the more salient differences between IDDM and NIDDM are summarized in Table 67.1. 

Singh, and A. Ghatak. Lipid-lowering efficacy of psyllium hydrophilic mucil- POOS 1 loid in non insulin dependent diabetes mellitus with hyperlipidaemia. Indian... 

Treating Diabetes Mellitus. There are two main types of diabetes. Type I diabetes (previously called insulin-dependent diabetes mellitus, IDDM) is a severe form which occurs most commonly in juveniles and young adults and which results from an absolute insulin deficiency arising from pancreatic B cell destruction, presumably via an immune-mediated mechanism. Type II diabetes (previously called non-insulin-dependent diabetes mellitus, NIDDM) is a milder, heterogeneous form of diabetes which occurs more... 

It is indicated in non-insulin dependent diabetes mellitus (type II, maturityonset diabetes) whenever treatment by diet alone proves to be inadequate. 

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