Dextropropoxyphen

C7H7ClMg 6921-34-2) see Bencyclane Clomifene Dextropropoxyphene Ritonavir 7V-benzylmaleimide... 

C HiqOj 123-62-6) see Alclometasone dipropionate Alfentanil Alphaprodine Beclometasone Dextropropoxyphene Diethylstilbestrol dipropionate Fentanyl Propiram Sulindac Testosterone propionate propanol... 

Ci)H f 0 93-55-0) see Amfeprainone Dextropropoxyphene Eprazinone Mephenytoin Phendimetrazine Phenmetrazine Phenylpropanolamine Tamoxifen... 

Pharmaceuticals) Ethinyl oestradiol, paracetamol, aspirin, dextropropoxyphene, clofibrate and oxytetracycline Aire river (UK), Lambro river (Italy) and Rur river (Germany) Surface water - Product consumption - Worst-case influent - Excreted post-metabolism - WWTP removal - River water die-away [50]... 

Dextropropoxyphene Carbarn azepine Increased plasma-concentration of carbamazepine... 

Dextropropoxyphene The (2i ,55)-enantiomer marketed as Darvon is an analgesic, whereas the (25,5i )-enantiomer called Novrad is an antitussive. 

O Neill WM, Flanks GW, White L, Simpson P, Wesnes K. (1995). The cognitive and psychomotor effects of opioid analgesics I. A randomized controlled trial of single doses of dextropropoxyphene, lorazepam, and placebo in healthy subjects. EurJ Clin Pharmacol. 48(6) 447-53. 

CftHii), had tail-flick activities in the codeine-dextropropoxyphene potency range (oral and intraperitoneal routes in rats) and nalorphine antagonized the actions of both codeine and (XLIV) (R = C H,) in this test [132]. 

There are also known cases of drug enantiomers that possess completely different therapeutic properties. The (+)-2/ ,35 -stereoisomer of propoxyphene (dextropropoxyphene) is marketed as an analgesic agent, whereas its enantiomer ( )-(25, 3/ )-propoxyphene (levopropoxyphene) is available as an effective anti-tussive agent [3]. The enantiomers of some chiral drugs are known to possess essentially identical qualitative and quantitative pharmacological activities, for example, the antihistamine promethazine, which is marketed as a racemate [5]. 

PROPOXYPHENE (Dextropropoxyphene) Relief of mild to moderate pain. REMIFENTANIL HYDROCHLORIDE ... 

Cimetidine, erythromycin, and dextropropoxyphene had no effect on the pharmacokinetics of MHD. Results with warfarin show no evidence of interaction with either single or repeated doses of oxcarbazepine. 

The most known narcotics are the opium alkaloids such as morphine, codeine, thebaine, papaverine, noscapine and their derivatives and modified compounds such as nalmorphine, apomorphine, apomopholcodine, dihydrocodeine, hydro-morphone and heroine, also known as diamorphine. Synthetic narcotics share the structural skeleton of morphine and include dextromethorphan, pentazocine, phenazocine meperidine (pethidine), phentanyl, anfentaitil, remifentalin, methadone, dextropropoxyphene, levoproxyphene, dipipanone, dextromoramide, meptazinol and tramadol. Thebaine derivatives are also modified narcotics and include oxycodone, oxymorphone, etorphine, buprenorphine, nalbuphine, naloxone or naltrexone. Narcotics can be semi-synthesized or totally synthesized from the morphine and thebaine model. The compounds serve various purposes in clinical practise. 

Rheumatological drugs Allopurinol Azapropazone Phenylbutazone Other Disulflram Dextropropoxyphene... 

Dextropropoxyphene 9-13 2.5 days Active toxic metabohte which in the elderly and in patients with decreased kidney function may build up (concentrate ) and cause confusion. Risk of pronounced respiratory depression together with alcohol intake. Low risk of abuse... 

Drugs having a chromophore like that of ephedrine include diphenhydramine, amphetamine, ibuprofen and dextropropoxyphene. 

Analysis was carried out by difference spectrophotometry. A one-point standard calibration for the determination of aspirin in dextropropoxyphene compound capsules was prepared by adding a known amount of aspirin to the sample from a standard stock solution. Stated content in the capsules ... 

Propoxyphene (dextropropoxyphene Darvon) is structurally related to methadone but is much less potent as an analgesic. Compared with codeine, propoxyphene is approximately half as potent and is indicated for the treatment of mild pain. It is not antipyretic or antiinflammatory like aspirin and is less useful than aspirin in most cases of mild pain. Toxicity from propoxyphene, especially in combination with other sedatives, such as alcohol, has led to a decrease in its use. Death following ingestion of alcohol in combination with propoxyphene can occur rapidly (within 20 minutes to 1 hour). The drug is not indicated for those with histories of suicide or depressive illnesses. 

Levopropoxyphene is the L-isomer of the analgesic agonist dextropropoxyphene. Levopropoxyphene is only mildly antitussive and is rarely used. It has no CNS effects. Side effects include dizziness and nausea. It is available as the napsylate derivative (Novrad) and is taken orally in the form of a liquid or less frequently as a capsule. 

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