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Metoprolol Dextropropoxyphene

A single-dose study has shown that the bioavailability of metoprolol is markedly increased by dextropropoxyphene and a case report supports these flndings. The bioavailability of propranolol is also increased, but to a lesser extent. [Pg.842]

Preliminary results of a study suggest that after taking dextropropoxyphene [dose not stated] for a day the bioavailability of a single 100-mg oral dose of metoprolol was increased by almost 260% and the total body clearance was reduced by 18% in healthy subjects. The bioavailability of a single 40-mg oral dose of propranolol was increased by about 70%. ... [Pg.842]

Dextropropoxyphene inhibits the metabolism of metoprolol and propranolol by the cytochrome P450 isoenzyme CYP2D6, which results in increased levels and therefore increased effects. Propranolol is probably affected to a lesser extent as it is also metabolised by CYP1A2. [Pg.842]

See other pages where Metoprolol Dextropropoxyphene is mentioned: [Pg.101]    [Pg.22]    [Pg.124]    [Pg.125]    [Pg.137]    [Pg.188]    [Pg.384]    [Pg.403]    [Pg.745]    [Pg.761]    [Pg.841]    [Pg.856]    [Pg.871]    [Pg.881]    [Pg.933]    [Pg.979]    [Pg.1025]    [Pg.1210]    [Pg.1221]    [Pg.1241]    [Pg.1319]    [Pg.1366]    [Pg.1450]    [Pg.1463]    [Pg.842]    [Pg.22]    [Pg.124]    [Pg.125]    [Pg.188]    [Pg.228]    [Pg.384]    [Pg.659]    [Pg.856]    [Pg.871]    [Pg.881]    [Pg.933]    [Pg.979]    [Pg.1025]    [Pg.1221]    [Pg.8]    [Pg.231]    [Pg.254]    [Pg.401]    [Pg.407]    [Pg.624]   
See also in sourсe #XX -- [ Pg.842 ]



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Dextropropoxyphen

Metoprolol

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