Alclometasone 17,21-Dipropionate

Molecular formula C28H37CIO7 Molecular weight 521.05 CAS Registry No 66734-13-2 Merck Index 13,219 [Pg.18]

Sample preparation Condition a 3 mL 500 mg Megabond MF CIS SPE (Varian) with 3 mL MeOH and 3 mL water. Sonicate 1 g cosmetic with 10 mL or MeOH dichloromethane 10 90 (depending on what appears visually to give b t solubility) at 40° for 10 min, centrifuge, collect the clear supernatant. Add 5 mL ot the supernatant to the SPE cartridge, wash with 4mL acetoneiwater 20 80, wash vwth 1 mL n-hexane, elute with 4 mL diethyl ether. Evaporate the eluate to dryness under reduced pressure, reconstitute the residue with 5 mL (or more) MeOH, inject a 10 p.L aliquot. [Pg.18]

Mobile phase Isocratic. MeCN water 60 40. Gradient. MeCNavater from 25 75 to 90 10 over 30 min, maintain at 90 10 for 10 min. [Pg.18]

Retention time k 2.55 (isocratic) 21.0 min (gradient) Limit of detection 300 ng/mL [Pg.18]

Gagliardi, L. De Orsi, D. Del Giudice, M.R. Gatta, P. Porr, R. Chimenti, P. Tonelli, D. Development of a tandem thin-layer chromatography-high-performance liquid chromatography method for the identification and determination of corticosteroids in cosmetic products, AnaLChim-Acta, 2002, 457, 187-198. [Pg.19]

C5HyNO 2141-62-0) see Thiamine Trimethoprim (llp,16a)-17,21-[(l-ethoxypropylidene)bis(oxy)]-ll-bydr-oxy-16-methylpregna-l,4,6 trienc-3,20-dione (02711360 672/2-72-0) see Alclometasone dipropionate... [Pg.2375]

C2jH3 07 67212-74-2) see Alclometasone dipropionate 2 -hydroxy-4 -(3-methyl-2-butenyloxy)acetophenone (C,3H] 03 24672-83-1) see Sofalcone 2-hydroxy-2-methylbutyric acid ethyl ester (C7H14O3 77-70-3) see Paramethadione 2-hydroxy-2-methylbutyronitrile (Ci H NO 4111-08-4) see Paramethadione 5(R)-(hydroxymethyl)-2-cyclopenten-l(R)-ol (C(jH,(,02 143395-28-2) see Abacavir 2-[l-(hydroxymethyl)cyclopropyl]acctonitrile (QH9NO 152922-71-9) see Montelukast sodium ( )-cis-2-hydroxymethyl-Af,Af-diethyl-l-phenylcyclo-propanecarboxamide... [Pg.2397]

C24H3 Ofi 13796-64-0) see Alclometasone dipropionate methyl (2R, 35)-4-acetoxy-2,3-epoxybutanoate (C7Hi()04 117069-14-4) see Carumonam methyl 4-[[5-(acetoxymethyl)-2-butylimidazol-l-yl]me-thyljbenzoate... [Pg.2411]

C HiqOj 123-62-6) see Alclometasone dipropionate Alfentanil Alphaprodine Beclometasone Dextropropoxyphene Diethylstilbestrol dipropionate Fentanyl Propiram Sulindac Testosterone propionate propanol... [Pg.2437]

C22H28O5 13954-10-4) see Alclometasone dipropionate lip,17,21-trihydroxypregna-l,4-diene-3,20-dione 21-chlo-roacetate... [Pg.2450]

Examples of group I, i.e. weak or low efficacy topical steroids, are hydrocortisone acetate in various concentrations, methylprednisolone 1.0% and prednisolone 0.5%. Group II, the moderately potent steroids, includes alclometasone dipropionate 0.05%, hydrocortisone butyrate 0.1%, triamcinolone acetonide 0.025% and fluocinolone ace-tonide 0.01%. Group III, the potent steroids, contains among others betamethasone valerate 0.1%, betamethasone dipropionate 0.05%, budesonide 0.025%, desoximetasone 0.05%, fluticasone propionate 0.05%, amcinonide 0.1%, fluocinonide 0.05% and mometasone furoate 0.1%. Group IV comprises the very potent agents such as clobetasol propionate 0.05% and halobetasol propionate 0.05%. [Pg.483]

Common Name Alclometasone dipropionate Perderm Modrasone... [Pg.132]

C9H2(103 115-80-0) see Alclometasone dipropionate Betamethasone dipropionate triethyl phosphate... [Pg.2449]

Alclometasone dipropionate Anti- inflammatory Eczema, dermatitis, allergies, and rash Aclovate 0.05... [Pg.290]

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