Oxcarbazepine Dextropropoxyphene

Cimetidine, erythromycin, and dextropropoxyphene had no effect on the pharmacokinetics of MHD. Results with warfarin show no evidence of interaction with either single or repeated doses of oxcarbazepine. 

Dextropropoxyphene may increase the plasma levels of antiepiieptics, particularly carbamazepine, see Carbamazepine or Oxcarbazepine + Dextropropoxyphene (Propoxyphene) , p.527. 

Carbamazepine serum levels can be raised by dextropropoxyphene. Toxicity may develop unless suitable dosage reductions are made. Oxcarbazepine appears not to interact with dextropro-pox3q hene. 

Dextropropoxyphene 65 mg three times daily for 7 days did not affect the steady-state levels of the active metabolite of oxcarbazepine in 7 patients with epilepsy or trigeminal neuralgia. ... 

The interaction between carbamazepine and dextropropoxyphene is very well established and clinically important. If concurrent use is necessary reduce the dosage of carbamazepine appropriately to prevent the development of toxicity. In many cases it may be simpler to use a non-interacting analgesic, although the occasional single dose of dextropropoxyphene probably does not matter. No special precautions seem necessary with oxcarbazepine. 

Mogensen PH, Jorgensen L, Boas J, Dam Vesterager A, Flesch G, Jensen PK. Effects of dextropropoxyphene on the steady-state kinetics of oxcarbazepine and its metabolites. Acta NeurolScand 992) 85, 14-17,... 

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