Testosterone propionate

Oil-soluble derivatives of testosterone itself predate those of its 19-nor congener these agents too are used to administer depot injections so as to provide in effect long-term blood levels of drug. Thus, acylation of testosterone with propionyl chloride in the presence of pyridine yields testosterone propionate (76a)acylation by means of decanoic anhydride yields testosterone decanoate (76b).Finally, reaction of 75 with 3-cyclopentylpropionyl chloride affords testosterone cypionate (76c)This last undergoes hydrolysis unusually slowly because of the presence of two substituents at the 5 position (see Newman s Rule of 6). ... 

Methyltestosterone Testosterone Testosterone Cypionate Testosterone Decanoate Testosterone Propionate... 

Terolidine 2, 56 Tesicam T79 Tesimide 296 Testolactone 160 Testosterone cypionate 1, 172 Testosterone decanoate T, 172 Testosterone propionate 1, 172 Tetrabenazine 350 Tetracaine 1, 110 Tetracycline 1, 212 Tetrahydrocannabinol, A-1, 1, 394... 

C HiqOj 123-62-6) see Alclometasone dipropionate Alfentanil Alphaprodine Beclometasone Dextropropoxyphene Diethylstilbestrol dipropionate Fentanyl Propiram Sulindac Testosterone propionate propanol... 

CHJH28O2 58-22-0) see Drostanolone Testosterone cypionate Testosterone enanthate Testosterone propionate Trilostane... 

The influence of gonadal hormones on prepubertal animals suggests some steroidal sensitivity in adults with regard to F. elicitation. Young male sheep are induced to perform F. in response to exogenous T and to 17-p-estradiol F. in female red deer is also sensitive to T injections (Parrott, 1978 Fletcher, 1978). Sex differences can interact with the hormonal state where social conditions vary. Female cats (intact) display F. to urine marks only in the absence of males testosterone propionate induced F. in spayed females towards estrous females (Verbeme, 1976 Hart and Leedy, 1987), whereas an ovarian hormone (estradiol) failed to elicit F. to males (intact, and sexually inactive), presumably indicative of social inhibition overriding steroid facilitation. 

This increase in enzyme activity can be prevented by the administration of actinomycin D [133] or an androgen such as testosterone propionate [134]. Pretreatment of partially hepatectomized rats with methotrexate markedly decreases the incorporation of orotic acid into DNA of the regenerating livers... 

Teratogenic effects, 257 Testosterone cypionate, 172 Testosterone decanoate, 172 Testosterone propionate, 172... 

Determination of dose-The number of pellets to be implanted depends upon the minimal daily requirement of testosterone propionate determined by a gradual reduction of the amount administered parenterally. The usual ratio is as follows Implant two 75 mg pellets for each 25 mg testosterone propionate required weekly. It has been found that approximately 33% of the material is absorbed in the first month, 25% in the second month, and 17% in the third month. Adequate effect of the pellets ordinarily continues for 3 to 4 months, sometimes as long as 6 months. 

Product interchange Do not use testosterone cypionate interchangeably with testosterone propionate because of differences in duration of action. 

Testosterone propionate (Neo-Hombreol, Oreton Propionate, others)... 

Breast carcinoma IM (testosterone aqueous) 50-100 mg 3 times a week. IM (testosterone cypionate ortestosterone ethanate) 200-400 mg q2-4wk. IM (testosterone propionate) 50-100 mg 3 times a week. 

Testosterone propionate, though potent, has a short duration of action and is not practical for long-term use. Testosterone undecanoate can be given orally, administering large amounts of the steroid twice daily (eg, 40 mg/d) however, this is not recommended because oral... 

Smith, E. (1967). Application of reverse phase partition chromatography to the analysis of testosterone propionate in oil injectables. J. Pharm. Sci., 56(5), 630-634. 

Testosterone propionate, 409 Testosterone tetrahydropyranyl ether, 43 Testosterone tosylate, 445, 449... 

A German report of a 22-year-old male body-builder who had taken both testosterone propionate and nandrolone decanoate in rising doses over a period of 4 months detailed the emergence of fulminant acne, a sternoclavicular bone lesion, and loss of libido (77). Severe acne after excessive androgen use has been reported before, and the apparently osteoarthritic complication in this case was probably secondary to the acne. 

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