Spectrometric detection, simultaneous

Amirav A, Jing H. 1998. Simultaneous pulsed flame photometric and mass spectrometric detection for enhanced pesticide analysis capabilities. J Chromatogr 814 133-150. 

Plasma sources were developed for emission spectrometric analysis in the late-1960s. Commercial inductively coupled and d.c. plasma spectrometers were introduced in the mid-1970s. By comparison with AAS, atomic plasma emission spectroscopy (APES) can achieve simultaneous multi-element measurement, while maintaining a wide dynamic measurement range and high sensitivities and selectivities over background elements. As a result of the wide variety of radiation sources, optical atomic emission spectrometry is very suitable for multi-element trace determinations. With several techniques, absolute detection limits are below the ng level. 

Cuyckens F and Claeys M. 2002. Optimization of a liquid chromatography method based on simultaneous electrospray ionization mass spectrometric and ultraviolet photodiode array detection for analysis of flavonoid glycosides. Rapid Commun Mass Spectrom 16(24) 2341—2348. 

Zeng H., Deng Y., and Wu J., 2003a. Fast analysis using monolithic columns coupled with high-flow online extraction and electrospray mass spectrometric detection for the direct and simultaneous quantitation of multiple components in plasma. J Chromatogr B 788 331. 

LC-MS/MS has dramatically changed the way bionalysis is conducted. Accurate and precise quantitation in the pg ml scale is nowadays possible however one has to be aware of certain issues which are specific to mass spectrometric detection such as matrix effects and metabolite crosstalk. With the current growing interest in the analysis of endogenous biomarkers in biological matrices, quantitative bioanalysis with MS has certainly the potential to contribute further in this field with the development of multicomponent assays. Modern triple quadrupole instruments have the feature to use very short dwell times (5-10 ms), allowing the simultaneous determination of more than 100 analytes within the timescale of an HPLC peak. Due to the selectivity of the MS detection the various analytes... 

A direct mass spectrometric method for simultaneous detection of five benzimidazoles including levamisole, thiabendazole, mebendazole, fenbendazole, and febantel in sheep milk was reported (377). The method, which involves injection of crude milk extracts and selection and collision of the most abundant ionic species obtained under electron impact ionization, was highly sensitive and rapid. Another direct mass spectrometric approach for rapid and quantitative determination of phenothiazine in milk was also described (323). This method involves an extraction step using a Cig microcolumn disc, followed by thermal desorption of the analyte from the disc directly into an ion trap mass spectrometer. 

Taylor EW, Qian MG, Dollinger GD. Simultaneous online characterization of small organic molecules derived from combinatorial libraries for identity, quantity, and purity by reversed-phase HPLC with chemiluminescent nitrogen, UV, and mass spectrometric detection. Anal Chem 1998 70 3339-3347. 

Matthias et al. [216] have described a comprehensive method for the determination of aquatic butyltin and butylmethyltin species at ultratrace levels using simultaneous sodium borohydride hydridisation, extraction with gas chromatography-flame photometric detection and gas chromatography-mass spectrometric detection. The detection limits for a lOOmL sample were 7ng L 1 of tin for tetrabutyltin and tributyltin, 3ng L 1 of tin for dibutyltin and 22ng L 1 tin for monobutyltin. For 800mL samples detection limits were l-2ng L 1 tin for tri- and tetrabutyltin and below lng L 1 tin for dibutyltin. The technique was applied to the detection of biodegradation products of tributyltin in non saline waters. 

Source compensation Pulse-to-pulse intensity variations and intensity fluctuations in the spectrometric excitation source are often the dominant noise source affecting the performance of the detection system. However, since OIDs are parallel multichannel detectors, these intensityvariations do equally and simultaneously affect the entire spectral distribution as a whole. Thus, with the aid of a single-channel reference detector, monitoring a portion of the source s light flux, it is possible to accurately normalize for spectrum-to-spectrum variations and practically eliminate these and any other source flicker noise related effects. 

Stdggl, W. Huck, C. Wongyai, S. Scherz, H. Bonn, G. 2005. Simultaneous determination of carotenoids, tocopherols and, y-oryzanol in crude rice bran oil by liquid ehromatography eoupled to a diode array and mass spectrometric detection employing silica C30 stationary phases. J. Sep. Sci. 28 1712-1718. 

Wang, K.D., Chen, P.S., Huang, S.D. Simultaneous derivatization and extraction of chloro-phenols in water samples with up-and-down shaker-assisted dispersive liquid-liquid microextraction coupled with gas chromatography/mass spectrometric detection. Anal. Bioanal. Chem. 406, 2123-2131 (2014)... 

A flame spectrometric detection (FSD) system was used to study a variety of metal chelates including the UO(tfac)2, Cr(tfac)3, Cr(hfac)3, Al(tfac)3, Cu(tfac)2, Fe(hfac)2, Cu(hfac)2, Co(hfac)2 and tricarbonylchromium complexes. The GC column was connected by a heated stainless steel line to a flame spectrometer, working in a laminar flow regime with a N2O-C2H2 premix burner that could be heated without distortion of the flame, and a monochromator provided the selective response required for the FSD. The system included a splitter to allow simultaneous FID and FSD chromatograms . ... 

Gas chromatographic methods with flame ionization or mass spectrometric detection that have been applied to the determination of VMA are highly specific and can simultaneously determine VMA and HPLC is, however,... 

Taylor, E.W. Qian, M.G. Dollinger, G.D. Simultaneous Online Characterization of Small Organic Molecules Derived from Combinatorial Libraries for Identity, Quantity, and Purity by Reversed-Phase HPLC with Chemiluminescent Nitrogen, UV, and Mass Spectrometric Detection, Anal. Chem. 70,3339-3347 (1998). 

Zeng, H. Deng, Y Wu, J.-T. Past Analysis Using Monolithic Columns Coupled with High-flow On-line Extraction and Electrospray Mass Spectrometric Detection for the Direct and Simultaneous Quantitation of Multiple Components in Plasma, J. Chromatogr, B 788,331-337 (2003). 

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