Plasmacytoid dendritic cells

Lanzavecchia A Specialization and complementar- 57 ity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol 2001 31 3388-3393. 

Ito X Kanzler H. Duramad O. Cao W, Liu YJ Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid pre-dendritic cells. Blood 2006 107 2423-2431. 

De Heer HJ. Hammad H. Soullie T. Hijdra D, Vos N, Willart MA. Hoogsteden HC. Lambrecht BN Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 2004 200 89-98. 

Lore K, Smed-Sorensen A, Vasudevan J, Mascola JR, Koup RA (2005) Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4-t T cells. J Exp Med... 

Fig. 2. Chemokine receptors on DC subtypes. mDCpre, myeloid dendritic cell precursor pDCpre, plasmacytoid dendritic cell precursor.

O Keeffe M, Hochrein H, Vremec D, et al. Dendritic cell precursor populations of mouse blood identification of the murine homologues of human blood plasmacytoid pre-DC2 and CDllc+ DC1 precursors. Blood 2003 101(4) 1453-1459. 

Yoneyama H, Matsuno K, Zhang Y, et al. Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules. Int Immunol 2004 16(7) 915-928. 

Langenkamp A, Nagata K, Murphy K, Wu L, Lanzavecchia A, Sallusto F. Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells. Eur J Immunol 2003 33 474 182. 

DC, dendritic cell EC, endothelial cell EpC, epithelial cell FDC, follicular dendritic cell FDL, foot draining lymph FLS, fibroblast-like synoviocyte MC, mast cell MDDC, monocyte-derived dendritic cell MLS, macrophage-like synoviocyte MNC, mononuclear cell Mo, monocyte M0, macrophage OB, osteoblast pDC, plasmacytoid dendritic cell PMNs, polymorphonuclear neutrophils SC, stromal cell STC, synovium tissue cell TB, trabecular bone. 

Lande R, Giacomini E, Serafini B, et al. Characterization and recruitment of plasmacytoid dendritic cells in synovial fluid and tissue of patients with chronic inflammatory arthritis. J Immunol 2004 173(4) 2815-2824. 

Marshall, J.D. et al., Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions, J Leukoc. Biol, 73, 781,... 

ColonnaM, Trinchieri G. Liu YJ Plasmacytoid dendritic cells in immunity. Nat Immunol 2004 5 1219-1226. 

Jahnsen FL, Lund-Johansen F, Dunne JF, parkas L, Haye R, Brandtzaeg P Experimentally induced recruitment of plasmacytoid (CD123 ) dendritic cells in human nasal allergy. J Immunol 2000 165 4062-4068. 

Kang HK, Liu M, Datta SK Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-spe-cific regulatory T cells and contraction of inflammatory Thl7 cells. J Immunol 2007 178 7849-7858. 

Peripheral blood mononuclear cells (PBMCs) that include mainly monocytes, T-cells, and B-cells, and smaller portions of NK cells and dendritic cells of myeloid and plasmacytoid origin, are a critical component of immune system. PBMC-based models are widely used in research of cell-mediated immunity and for screening of compounds for immunomodulatory effects. 

Decalf, J., et al. (2007) Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients. J Exp Med. 204, 2423-37. 

Penna G et al Vitamin D receptor agonists in the treatment of autoimmune diseases Selective targeting of myeloid but not plasmacytoid dendritic cells. J Bone Min Res 2007 22(Suppl 2) 69. 

Schroeder, J. T., Bieneman, A. P., Xiao, H. et al. 2005. TLR9- and FceRI-mediated responses oppose one another in plasmacytoid dendritic cells by down-regulating receptor expression, J Immunol 175 5724-5731. 

Lund JM, Linehan MM, Iijima N, Iwasaki A. Cutting edge plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. J Immunol 2006 177 7510-4. 

The lymph node harbors a composite population of dendritic cells (DCs)—residents and emigrants—capable of selection, stimulation and elimination of effector lymphocytes. These cells trigger adaptive immunity and/or tolerance. In the human lymph node T-cell compartment, two primary subsets of DCs, compared to six in mice, have been identified monocytoid CD 1 lb CD 1 and plasmacytoid interferon (IFN)-a produc-... 

Krug A, Rothenfusser S, Hornung V, et al. Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol. 2001 31 2154-1263. 

Hornung V, Guenthner-Biller M, Bourquin C, et al. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med. 2005 11 263-270. 

H. Engelmann, S. Endres, A.M. Krieg, and G. Hartmann (2001) Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol 31 3026-3037. 

Hartmann, G., J. Battiany, H. Poeck, M. Wagner, M. Kerkmann, N. Lubenow, S. Rothenfusser, and S. Endres (2003) Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells. Eur J Immunol 33 1633-1641. 

Dendritic cells can either be generated from progenitors such as stem cells or CD14-I- monocytes, or isolated directly from the blood. Blood-derived DC are present as at least two distinct populations— myeloid and plasmacytoid DC. 

Nakano H, Yanagita M, Gunn MD CDllc(+)B220(+)Gr-l(-H) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J Exp Med 2001 194 1171-1178. 

Patterson S, Rai A, Hockey N et al. Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus. J Virol 2001 75 6710-6713. 

Pauls E, Shpiro N, Peggie M, Young ER, Sorcek RJ, Tan L, Choi HG, Cohen P. An essential role for IKKbeta in the production of type 1 inteferons by plasmacytoid dendritic cells. J Biol Chem. 2012 287 19216-28. doi 10.1074/jbc.Ml 12.345405. 

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