Curcumin-induced cell apoptosis

Mackenzie GG, Queisser N, Wolfson ML, Fraga CG, Adamo AM, Oteiza PI. 2008. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin s lymphoma cells. Int J Cancer 123 56-65. 

Tan TW, Tsai HR, Lu HF, Lin HL, Tsou MF, Lin YT, Tsai HY, Chen YF, Chung JG. 2006. Curcumin-induced cell cycle arrest and apoptosis in human acute promyelo-cytic leukemia HL-60 cells via MMP changes and caspase-3 activation. Anticancer Res 26 4361-4371. 

The effect of curcumin on apoptosis in multidmg-resistant cell lines has been reported. Piwocka et al. ° demonstrated that curcumin induced cell death in multidrag-resistant CEM(P-gp4) and LoVo(P-gp4) cells in a caspase-3-independent maimer. Mehta et al. also examined the antiproliferative effects of curcumin against multidrag-resistant (MDR) lines, which were found to be highly sensitive to curcumin. The growth-inhibitory effect of curcumin was time- and dose-dependent and was correlated with its inhibition of ornithine decarboxylase activity. Curcumin preferentially arrested cells in the G2/S phase of the cell cycle. 

Anto RJ, Maliekal TT, Karunagaran D. 2000. L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis. J Biol Chem 275 15601-15604. 

Cao J, Liu Y, Jia L, Zhou HM, Kong Y, Yang G. Jiang LP, Li QJ, Zhong LF. 2007a. Curcumin induces apoptosis through mitochondrial hypcrpolarization and mtDNA damage in human hepatoma G2 cells. Free Radic Biol Med 43 968-975. 

Collett GP, Campbell FC. 2004. Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells. Carcinogenesis 25 2183-2189. 

Jiang MC, Yang-Yen HF, Yen JJ, Lin JK. 1996. Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines. Nutr Cancer 26 111-120. 

Mukherjee Nee Chakraborty S, Ghosh U, Bhattacharyya NP, Bhattacharya RK, Dey S, Roy M. 2007. Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Mol Cell Biochem 297 31-39. 

Rajasingh J, Raikwar HP, Muthian G, Johnson C, Bright JJ. 2006. Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia. Biochem Biophys Res Commun 340 359-368. 

Rashmi R, Kumar S, Karunagaran D. 2005. Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. Carcinogenesis 26 713-723. 

Rashmi R, Kumar S, Karunagaran D. 2004a. Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. Carcinogenesis 25 1867-1877. 

Rashmi R, Santhosh Kumar TR, Karunagaran D. 2003. Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases. FEBS Lett 538 19-24. 

Shankar S, Chen Q, Sarva K, Siddiqui I, Srivastava RK. 2007. Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells Molecular mechanisms of apoptosis, migration and angiogenesis. J Mol Signal 2 10. 

Skommer J, Wlodkowic D, Pelkonen J. 2006. Cellular foundation of curcumin-induced apoptosis in follicular lymphoma cell lines. Exp Hematol 34 463-474. 

Weir NM, Selvendiran K, Kutala VK, Tong L, Vishwanath S, Rajaram M, Tridanda-pani S, Anant S, Kuppusamy P. 2007. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther 6 178-184. 

Tourkina E, Gooz P, Oates JC, Ludwicka-Bradley A, Silver RM, Hoffman S. 2004. Curcumin-induced apoptosis in scleroderma lung fibroblasts role of protein kinase cepsilon. Am J Respir Cell Mol Biol 31 28-35. 

Bush, J.A., Cheung, K.J.J. and Li, G. (2001) Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53. Experimental Cell Research 271 (2), 305-314. 

Chen, H., Zhang, Z.S., Zhang, Y.L., and Zhou, D.Y., Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma ceBs, Anticancer Res., 19, 3675, 1999. 

Piwocka, K., Bielak-Mijewska, A., and Sikora, E., Curcumin induces caspase-3-independent apoptosis in human multidmg-resistant cells, N.Y. Acad. Set, 973, 250-254,2002. 

Choudhuri, T., Pal, S., Agwarwal, M. L., Das, T., and Sa, G. 2002. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Letters, 512(1-3), 334-340. 

Curcumin represents a covalent inhibitor of CBP. Beyond, it showed anti-angiogenic effects and is currently in phase II/III of clinical trials for cancer therapy, as well as in phase II for Alzheimer s disease and psoriasis [21, 22[. Garcinol, a potent inhibitor of PCAF and p300 (IC50 = 5 and 7 J-M, respectively) was found to induce apoptosis and alter global gene expression in HeLa cells. It was identified to repress chromatin transcription. N one of these inhibitors had effects on H D AC activity or on histone-free DNA transcription [23]. 

The in vitro antitumor activity of curcumin in HPV-associated cells has been established [Roy et al., 2002]. Curcumin modulates the in vitro expression and function of Pgp in multidrug-resistant human KB-V1 cells [Anand et al., 2008 Chearwae et al., 2004] and sensitizes cisplatin-resistant SiHa cells to cisplatin-induced apoptosis [Venkatraman et al., 2005], indicating its ability to reverse MDR in cervical cancer cells. The effect of curcumin in HPV-associated cells was found to involve the down-regulation of viral oncogenes, NF-kB and AP-1 [Anand et al., 2008 Divya and Pillai, 2006],... 

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