Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Counter-Receptor

The leukocyte integrin a 4(3 1 (also known as VLA-4 and CD49d/CD29) is a cell adhesion receptor, which is predominantly expressed on lymphocytes, monocytes and eosinophils. VLA-4 is generally selective for the CS1 domain within fibronectin, with an essential requirement for LDV sequence for binding. VLA-4 also binds to VCAM-1 as a counter receptor. [Pg.637]

Restivo VA Jr, Lombard LA. Gray GS. Nadler LM Cloning of B7-2 a CTLA-4 counter-receptor that 79 costimulates human T cell proliferation. Science 1993 262 909-911. [Pg.40]

Freeman, G. J. et al., Uncovering of functional alternative CTLA-4 counter receptor in B7-deficient mice, Science 262, 907-909, 1993. [Pg.274]

B7-H4 are upregulated on the surface of DCs upon contact with Tregs [15, 16]. Although for both molecules the counter-receptor is not known, it is most likely that immunosuppressive signals will be conveyed. Functional data concerning B7-H3 and B7-H4 are still limited, since they have been described rather recently. Nevertheless, similar to other members of the B7-H family, B7-H3 has clear immunosuppressive functions, as this molecule has been shown to mediate the reduction of autoimmune EAE and addition of recombinant B7-H3 molecules to mixed leukocyte reactions suppresses T-cell proliferation in vitro [17-20]. [Pg.31]

Probably the smallest sequence known to be responsible for receptor recognition is the RGD-tripeptide, initially discovered in fibronectin [143]. However, the specificity of the interaction with different integrins, the counter receptors of RGD sequences on the cell surface, is established by the flanking sequences of the RGD motif and the conformation of the tripeptide. In other words, the presentation of the RGD sequence is important for specific recognition by individual integrins. [Pg.302]

E-cadherin is unique in that it not only, like other cadherin family members, mediates homophilic adhesion to establish and maintain cellcell contacts, it also serves as a counter-receptor for integrins Oe/37 (Cepek et al, 1994) and (Whittard et al, 2002) in heterophilic adhesion. In fact, the interaction between E-cadherin on mucosal epithelial cells and Oe/S on intraepithelial lymphocytes has been the best characterized tissue-specific interaction for lymphocyte retention. Although structure of binding domains between E-cadherin and is not available, mutagenesis... [Pg.51]

Vachino, G, Chang, X-J, Veldman, G M, Kumar, R, Sako, D, Eouser, L A, Bemdt, M C, Cumming, D A, P-selectin glycoprotein ligand-1 is the major counter-receptor for P-selectin on stimulated T cells and is widely distributed in non-functional form on many lymphocytic cells, J. Biol Chem., 270, 21966-21974, 1995. [Pg.869]

Gut-tropic cells in humans express the o4/87 inte-grin, which is a counter-receptor for the mucosal vascular addressin MadCam-1 expressed on high endothelial venules of Peyer s patches and mesenteric lymph nodes, and on the endothelium of the gut mucosa (Briskin etal.,... [Pg.24]

Other members of the Ig-superfamily function in conjunction with counter-receptors from separate families of adhesion molecules in various events such as leukocyte trafficking and the movement of immune cells and probably tumor cells across cell barriers in inflammation and metastasis. These glycoproteins (Fig. 10) are the immune cell adhesion molecules ICAM-1, -2 and -3, the vascular cell adhesion molecule VCAM and the platelet-endothelial cell adhesion molecule PECAM [131-134]. [Pg.525]

VONDERHEIDE, R.H. SPRINGER, T.A. (1992) Lymphocyte adhesion through the very late antigen 4 evidence for a novel binding site in the alternatively spliced domain of VCAM-1 and an additional a4 integrin counter receptor on stimulated endothelium. Journal of Experimental Medicine, 175, 1433-1442. [Pg.26]


See other pages where Counter-Receptor is mentioned: [Pg.953]    [Pg.553]    [Pg.192]    [Pg.37]    [Pg.29]    [Pg.29]    [Pg.29]    [Pg.29]    [Pg.29]    [Pg.29]    [Pg.47]    [Pg.47]    [Pg.47]    [Pg.48]    [Pg.51]    [Pg.51]    [Pg.53]    [Pg.54]    [Pg.54]    [Pg.56]    [Pg.953]    [Pg.412]    [Pg.774]    [Pg.146]    [Pg.330]    [Pg.146]    [Pg.1788]    [Pg.1789]    [Pg.24]    [Pg.230]    [Pg.522]    [Pg.524]    [Pg.525]    [Pg.576]    [Pg.582]    [Pg.582]   
See also in sourсe #XX -- [ Pg.582 ]




SEARCH



© 2024 chempedia.info