P-selectin glycoprotein ligand

P-selectin EC, platelets P-selectin glycoprotein ligand-1 (PSGL-1) Sialyl-Lewis" and others... 

Fig. 1. Surface phenotype of HSPCs. Primitive HSPCs have the phenotype of c-KitThy-ll0WLin CD34+CD33 in humans, and the mouse counterparts have the phenotype of c-KifThy-llowLin Sca-l+. Primitive HSPCs express CXCR4 as the major chemokine receptor and various adhesion molecules such as VLA-4, VLA-5, LFA-1, P-selectin glycoprotein ligand-1 (PSGL-1), and CD44 for migration to the stem cell niche.

Wang K, Zhou Z, Zhou X, et al. Prevention of intimal hyperplasia with recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in the porcine coronary artery balloon injury model, J Am Coll Cardiol 2001 38 577-582,... 

Mehta, P, Cummings, R D, McEver, R P, Affinity and kinetic analysis of P-selectin binding to P-selectin glycoprotein ligand-1, J. Biol Chem., 273, 32506-32513, 1998. 

Vachino, G, Chang, X-J, Veldman, G M, Kumar, R, Sako, D, Eouser, L A, Bemdt, M C, Cumming, D A, P-selectin glycoprotein ligand-1 is the major counter-receptor for P-selectin on stimulated T cells and is widely distributed in non-functional form on many lymphocytic cells, J. Biol Chem., 270, 21966-21974, 1995. 

Another selectin target ligand whose carbohydrate stmcture has recently been characterized is P-Selectin Glycoprotein Ligand-1 (PSGL-1) (O Fig. 18) [200]. 

P-selectin is a major component in the early interaction between platelets and neutrophils, and endothelial cells, in the initial inflammatory response. A major ligand for P-selectin is P-selectin glycoprotein ligand-1 (PSGL-1), and this ligand is expressed on the surface of monocyte, lymphocyte, and neutrophil membranes. 

Figure 4 shows the allometric plots of pharmacokinetic parameters for the recombinant, soluble, and chimeric form of P-selectin glycoprotein ligand-1 (rPSGL-Ig), an antagonist to P-selectin for the treatment of P-selectin-mediated diseases like thrombosis, reperfusion injury, and deep vein thrombosis. Human rPSGL-Ig pharmacokinetic parameters could accurately be predicted on the basis of data from mouse, rat, monkey, and pig using allometric power functions [54]. 

Gardiner EE, De Luca M, McNally T, Michelson AD, Andrews RK, Bemdt MC Regulation of P-selectin binding to the neutrophil P-selectin counter-receptor P-selectin glycoprotein ligand-1 by neutrophil elastase and cathepsin G. Blood 2001 98 1440-1447. 

Jilma B, Heigovich N, Homoncik M, Marsik C, Kreuzer C, Jilma-Stohlawetz P Rapid down modulation of P-selectin glycoprotein ligand-1 (PSGL-1, CD 162) by G-CSF in humans. Transfusion 2002 42 328-333. 

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