Epithelial healing, corneal

Posterior subcapsuhr cataracts Ocular hypertension or glaucoma Secondary ocular infection Retardation of corneal epithelial healing Keratitis... 

Reed DB, Mannis MJ, Hills JF, Johnson CA. Corneal epithelial healing after penetrating keratoplasty using topical Healon versus balanced salt solution. Opthalmic Surg 1987 18 525-528 Reim M, Saric D. Treatment of chemical burns of the anterior segment with macromolecular sodium hyaluronate (Healon). Rosen ES (ed) Viscoelastic Materials Basic Science and Clinical Applications. New York, Pergamon Press, 1989, S. 203-215... 

AJW Huang, SCG Tseng. (1991). Corneal epithelial wound healing in the absence of limbal epithelium. Invest Ophthalmol Vis Sci 32 96-105. 

Introduced into ophthalmic practice in 1942, polyvinyl alcohol (PVA) is a water-soluble viscosity enhancer with both hydrophilic and hydrophobic sites. A common concentration used in ophthalmic preparations is 1.4%. PVA is useful in the treatment of corneal epithelial erosion and dry eye syndromes because it is nonirritating to the eye and actually appears to facilitate healing of abraded epithelium. It is used also to increase the residence time of drugs in the tears, aiding ocular absorption. 

Figure 6-4 (A) Severe toxic corneal epithelial desquamation after instillation of proparacaine 0.5%. (B) Same cornea 24 hours later, demonstrating the rapidity with which healing occurs.

Delayed corneal epithelial wound healing, PSC, decreased resistance to infection, decreased tear lysozyme, eyelid and conjunctiva hyperemia/edema/angioneurotic edema, subconjunctival hemorrhage, translucent blue sclera, increased lOP, myopia, exophthalmos, intracranial hypertension causing papilledema, diplopia, EOM paresis and eyelid ptosis, retinal hemorrhages (secondary to injection), central serous choroidopathy, abnormal ERGA EP, retinal embolic phenomenon (injection). 

An elderly man underwent vitreoretinal surgery for retinal detachment. Perfluorodecahn was used to repair the retina and was left in situ for 8 weeks and removed via the pars plana. One month later he developed a non-healing corneal epithelial defect associated with limbitis. Perfluorodecahn was found under the superior conjunctiva. A biopsy showed vacuoles in the conjunctival stroma surrounded by inflammatory cells. On surgical removal of the perfluorodecahn from the subconjunctival space, the epithelial defect healed. 

Stimulate appetite in AIDS Lambert-Eaton myasthenic syndrome and Charcot-Marie tooth disease Trypanosoma brucei gambiense (sleeping sickness) Pneumocystis carinii pneumonia in AIDS organ transplant recipients Corneal epithelial regeneration and healing Anemia associated with end-stage renal disease Anemia associated with end-stage renal disease Primary pulmonary hypertension Acute lymphocytic leukemia... 

Nutritional vitamin A deficiency causes xerophthalmia, a progressive disease characterized by night blindness, xerosis (dryness), and keratomalacia (comeal thinning), which may lead to perforation xerophthalmia may be reversed with vitamin A therapy. However, rapid, irreversible blindness ensues once the cornea perforates. Vitamin A also is involved in epithelial differentiation and may have some role in corneal epithelial wound healing. There is no evidence to support using topical vitamin A for keratoconjunctivitis sicca in the absence of a nutritional deficiency. 

Ubels, J. L., Edclhauscr, H. R., and Shaw, D. (1982), Measurement of comeal epithelial healing rate.s and corneal thickncs.s for evaluation of ocular toxicity of chemical substancc,s. J. To.xicol Cutaneous Ocular Ta.xicol. 1, 133-146. 

Nakamura M, Sato N, Chikama TI, Hasegawa Y, Nishida T. Hyaluronan facilitates corneal epithelial wound healing in diabetic rats. Exp Eye Res 1997 64 1043-1050. 

While pain after photorefractive keratectomy needs to be treated effectively, the non-prescribed long-term misuse of local anesthetics can lead to impaired wound healing. Postulated mechanisms include inhibition of corneal epithelial migration and adhesion and toxic effects on stromal keratocytes [49 , 50 ]. 

Dale, P.D., Maini, P.K., and Sherratt, J.A., Mathematical modeling of corneal epithelial wound healing. Math. Biosci, 1994,124 127-147. 

Effect of Topical Fluconazole on Corneal Epithelial Wound Healing... 

Tissue repair is a very important process in eye irritation, particularly corneal lesions, but has rarely been studied. Epithelial migration and proliferation are the primary events occurring after epithelial injury. It has been shown that fibronectin stimulates epithelial cell migration, whereas hyaluronic acid is more active on proliferation (Salonen et aL, 1991 Inoue and Katakami, 1993). Growth factors (EGF, FGF, etc.) have also been shown to play a role in corneal epithelial and endothelial wound healing (Dabin and Courtois, 1991 Raphael et al. 1993 Hoppenreijs et al., 1994). The effects of chemicals on the synthesis of these components by corneal cells could be extremely important in the modulation of repair processes. 

Dabin, I. and Courtois, Y., 1991, Acidic fibroblast growth factor overexpression in corneal epithelial wound healing, Growth Factors, 5 129. 

INFLUENCE OF CHRONIC ALCOHOLIC INTOXICATION ON HEALING OF CORNEAL EPITHELIAL DEFECTS. EFFECTIVITY OF TREATMENT BY PROTEASE INHIBITOR CONTRYCAL (APROTININ) AND AUTOLOGOUS FIBRONECTIN... 

Dale, P. D., P. K. Maini, and J. A. Sherratt. 1994. Mathematical modeling of corneal epithelial woimd healing. Math Biosci 124 127-147. 

Dastgheib KA, Clinch TE, Manche EE, Hersh P, Ramsey J. Sloughing of corneal epithelium and wound healing complications associated with laser in situ keratomileusis in patients with epithelial basement membrane dystrophy. Am J Ophthalmol 130 297-303 (2000). 

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