Basement membrane dystrophy

Dastgheib KA, Clinch TE, Manche EE, Hersh P, Ramsey J. Sloughing of corneal epithelium and wound healing complications associated with laser in situ keratomileusis in patients with epithelial basement membrane dystrophy. Am J Ophthalmol 130 297-303 (2000). 

Rosenberg ME, Tervo TM, PetroU WM, Vesaluoma MH. In vivo confocal microscopy of patients with corneal recurrent erosion syndrome or epitheUal basement membrane dystrophy. Ophthalmology 2000 107 565-573. 

Sridhar MS, Rapuano CJ, Cosar CB, et al. Phototherapeutic keratectomy versus diamond burr polishing of Bowman s membrane in the treatment of recurrent corneal erosions associated with anterior basement membrane dystrophy. Ophthalmology 2002 109 674-679. 

A 51-year-old woman underwent photo-refractive keratectomy and 7 days later developed epithelial basement membrane dystrophy in both corneas. After repeat keratectomy and antibiotic treatment she returned on day 3 with impaired vision, large epithelial defects, and corneal infiltrates in both eyes. Cultures were negative. She had continued to instill non-prescribed comfort drops made up of a 0.05% tetracaine solution every 30 minutes in both eyes from the initial surgery. She was asked to stop using the drops, and 2 weeks later the eyes had fully re-epithelialized, the infiltrates had begun to clear, and vision improved. 

Spontaneous comeal dystrophy and generalized basement membrane changes in Fischer-344 rats. Toxicol Path. 20 357 (1992). 

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