Intracranial hypertension

Suarez JI, Qureshi AI, Bhardwaj A, Williams MA, Schnitzer MS, Mirski M, Hanley DF, Ulatowski JA. Treatment of refractory intracranial hypertension with 23.4% saline. Crit Care Med 1998 26(6) 1118-1122. 

Qureshi A, Suarez JI. Use of hypertonic saline solutions in treatment of cerebral edema and intracranial hypertension. Crit Care Med 2000 28(9) 3301-3313. 

Lee K, Melinosky C, Cacciola J, Bodock M, Guanci M, Rordorf G, Badjatia N. Hypertonic sahne therapy for intracranial hypertension refractory to mannitol. Neurology 2005 64 S305. 

Management of Intracranial Hypertension (Intracranial Pressure >20 mmHg)... 

Hyperventilation to 25-30 mmHg for brief periods may be considered in refractory intracranial hypertension ° Effect limited to 24 h... 

Tetracyclines inhibit P. acnes, reduce the amount of keratin in sebaceous follicles, and have antiinflammatory properties (inhibiting chemotaxis, phagocytosis, complement activation, and cell-mediated immunity). Drawbacks to tetracyclines include hepatotoxicity and predisposition to infections (e.g., vaginal candidiasis). Other adverse effects include GI disturbances, photosensitivity, tooth discoloration in children, and inhibition of skeletal growth in the developing fetus. Tetracyclines must not be combined with systemic retinoids because of an increased risk of intracranial hypertension. / Tetracycline is the least expensive agent in this class and is often... 

Idiopathic intracranial hypertension There have been reports of idiopathic intracranial hypertension. A cardinal sign of idiopathic intracranial hypertension is papilledema early symptoms may include headache (associated with a change in frequency, pattern, severity, or persistence of particular importance are those headaches that are unremitting in nature) and visual disturbances. 

Danazol has been associated with several cases of benign intracranial hypertension also known as pseudotumor cerebri. Early signs and symptoms of benign intracranial hypertension include papilledema, headache, nausea, and vomiting, and visual disturbances. Screen patients with these symptoms for papilledema and, if present, advise the patients to discontinue danazol immediately and refer them to a neurologist for further diagnosis and care. 

Intracranial hypertension Danazol has been associated with several cases of benign intracranial hypertension (also known as pseudotumor cerebri) (see Black Box Warning). 

Pseudotumor cerebri Pseudotumor cerebri (benign intracranial hypertension) in adults has been associated with tetracycline use. 

Cardiovascular - Benign intracranial hypertension (pseudotumor cerebri) has been reported rarely. Bulging fontanels, as a sign of benign intracranial hypertension in infants, have been reported rarely. Changes in electrocardiogram (eg, nonspecific ST/T wave changes, bundle branch block) have been reported in association with pulmonary reactions. 

Benign intracranial hypertension (pseudotumor cerebri) occurs rarely. 

Superinfection (especially fungal), anaphylaxis, and benign intracranial hypertension occur rarely. 

Monitor the patient s LOG because of the potential for benign intracranial hypertension... 

Unlabeled Uses Intracranial hypertension, psychiatric interviews, sedative withdrawal, drug abuse withdrawal... 

The most important adverse effect observed with mecasermin is hypoglycemia. To avoid hypoglycemia, the prescribing instructions require consumption of a meal or snack 20 minutes before or after mecasermin administration. Several patients have experienced intracranial hypertension and asymptomatic elevation of liver enzymes. 

Mecasermin Recombinant form of IGF-1 that stimulates IGF-1 receptors Restores normal growth and metabolic IGF-1 effects in individuals with IGF-1 deficiency Replacement in IGF-1 deficiency that is not responsive to exogenous GH SC injection 2 x/d also contains recombinant human IGF-binding protein-3, which prolongs the half-life of the rIGF-1 Toxicity Hypoglycemia, intracranial hypertension, increased liver enzymes... 

Long-term glucocorticoid treatment can result in papilledema and increased intracranial pressure (the syndrome of pseudotumor cerebri or so-called benign intracranial hypertension ), particularly in children. 

Benign intracranial hypertension occurred in a 7-month-old child after withdrawal of topical betamethasone ointment and in a 7-year-old boy treated with a 1% cortisol ointment in large amounts. 

A 6-year-old girl, who had taken prednisone for 2.5 years for nephrotic syndrome with seven relapses in 3 years, developed symptoms of benign intracranial hypertension after oral glucocorticoid dosage reduction over 10 months from 30 mg/day to 2.5 mg/every other day (46). Laboratory studies and head CT scan were normal, but there was bilateral papilledema and the cerebrospinal fluid pressure was increased. She was given prednisone 1 mg/kg/day initially, with acetazola-mide, and 25 ml of cerebrospinal fluid was removed. All her symptoms resolved and treatment was gradually withdrawn. She developed no further visual failure. 

An encephalopathy can occur at any age (SEDA-18, 387), not necessarily in association with intracranial hypertension. 

Benign intracranial hypertension with nasal glucocorticoids has been reported (439). 

Lorrot M, Bader-Meunier B, Sebire G, Dommergues JP. Hypertension intracranienne benigne une complication meconnue de la corticotherapie. [Benign intracranial hypertension an unrecognized complication of corticosteroid therapy.] Arch Pediatr 1999 6(l) 40-2. 

Bond DW, Charlton CP, Gregson RM. Benign intracranial hypertension secondary to nasal fluticasone propionate. BMJ 2001 322(7291) 897. 

A 32-year-old woman who was not obese developed benign intracranial hypertension in association with ovarian hyperstimulation syndrome after ovulation induction using goserelin, follitropin, and human chorionic gonadotropin (hCG) (3). The syndrome did not recur during a second pregnancy in which follitropin and hCG were not used... 

Lesny P, Maguiness SD, Hay DM, Robinson J, Clarke CE, Killick SR. Ovarian hyperstimulation syndrome and benign intracranial hypertension in pregnancy after in-vitro fertilization and embryo transfer case report. Hum Reprod 1999 14(8) 1953-5. 

A 32-year-old woman who was not obese developed benign intracranial hypertension in association with... 

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