Colon carcinogenesis azoxymethane induced

Tanaka, T., Kohno, H., Suzuki, R., Yamada, Y, Sugie, S., and Mori, H. (2003) A novel inflanunation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci. 94, 965-973. 

Tanaka, T. et al., Suppression of azoxymethane-induced rat colon carcinogenesis by dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during the post-initiation phase, Carcinogenesis, 16, 2957, 1995. 

H. Narahara, M. Tatsuta, H. lishi, M. Baba, N. Uedo, N. Sakai, H. Yano and S. Ishiguro, K-ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all-trans-retinoic acid, Int. J. Cancer, 2000, 88(2), 157. 

The simple chalcone 70 has distributed widely in Glycyrrhizin plants as a minor constituent, and its glycosides are main flavonoids of licorice as described in Chapter 1. Recently, Okuyama et al. reported inhibition effect of the chalcone (70) on azoxymethane-induced murine colon aberrant crypt foucus formation and carcinogenesis [116]. 

Ju J, Liu Y, Hong J, Huang MT, Conney AH, Yang CS. 2003. Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse model. Nutr Cancer 46 172-178. 

Fiber was shown to inhibit carcinogenicity of 2-acetylaminofluorene more than thirty years ago (7,17). A recent review (18) has pointed out the lack of consistency in studies of fiber effects on experimental colon carcinogenesis. Investigators use different strains of rat, stock or semipurified diets, and different carcinogens administered orally, subcutaneously or intrarec-tally (Table v). Ward et al. (19) found cellulose to have no effect on the carcinogenicity of azoxymethane (AOM) in male Fisher rats fed a semipurified diet. Freeman et al. (20), on the other hand, found cellulose to protect male Wistar rats from colon cancer induced by subcutaneous injection of 1,2-dimethylhydrazine (DMH). 

Continuous feeding of rats with 1% fenugreek seed powder (FSP) and 0.05% and 0.10% diosgenin suppressed total colonic aberrant crypt foci (ACF) by up to 32, 24 and 42%, respectively, in azoxymethane-induced carcinogenesis in rats. During the promotional stages, FSP inhibited total ACF. 

Rao, C.V., Simi, B., and Reddy, B.S., Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis (London), 14, 2219, 1993. 

Ohkami, H., Tazawa, K., Yamashita, I., Shimizu, T., Murai, K., Kobashi, K. and Fujimaki, M. 1995. Effects of apple pectin on fecal bacterial enzymes in azoxymethane-induced rat colon carcinogenesis, Jpn. J. Cancer Res., 86(6) 523-529. 

Kohno H, Maeda M, Tanino M et al (2002) A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis. Cancer Lett 183 131-139... 

Rao CV, Rivenson A, KatiwaUa M, KeUoff GJ, Reddy BS, Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats. Cancer Res 1993 53 2502-2506. 

Sengupta, A., Ghosh, S., and Das, S., Tomato and garlic can modulate azoxymethane-induced colon carcinogenesis in rats, Rwr. J. Cancer Prev., 12,195,2003. 

Challa, A., Rao, D.R., Chawan, C.B., and Shackelford, 1,., Bifidobacterium longum and lactulose suppress azoxymethane-induced colonic aberrant crypt foci in rats. Carcinogenesis, 18, 517-521, 1997. 

Tanaka T, Makita H, Kawabara K, Mori H, Kakumoto M, Satoh K, Hara A, Sumida T, Tanaka T, Ogawa H (1997) Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin. Carcinogenesis 18 957... 

Reddy, B. S. Maeura, Y. (1984). Tumor promotion by dietary fat in azoxymethane-induced colon carcinogenesis in female F344 rats influence of amount and source of dietary fat. J. Natl Cancer Inst, 72(3), 745-50. 

Femia, A.P., Luceri, C., Dolara, P. et al. (2002) Antomutagenic activity of the prehiotic inuhn enriched with oligofructose in combination with probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane induced colon carcinogenesis in rats. Carcinogenesis, 23, 1953-1960. 

Kawamori, T., Tanaka, T., Hirose, Y., Ohnishi, M. and Mori, H. 1996. Inhibitory effects of rf-limonene on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. Carcinogenesis. 17(2) 369—372. 

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