Azoxymethane carcinogenesis

Sugie, S. et al., Inhibitory effects of plumbagin and jugloneon azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett., Ill, 111, 1998. 

Tanaka, T. et al., Suppression of azoxymethane-induced rat colon carcinogenesis by dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during the post-initiation phase, Carcinogenesis, 16, 2957, 1995. 

Reddy BS, Mori H and Nicolais M. 1981. Effect of dietary wheat bran and dehydrated citrus fiber on azoxymethane-induced intestinal carcinogenesis in Fischer 344 rats. J Natl Cancer Inst 66 553-557. 

H. Narahara, M. Tatsuta, H. lishi, M. Baba, N. Uedo, N. Sakai, H. Yano and S. Ishiguro, K-ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all-trans-retinoic acid, Int. J. Cancer, 2000, 88(2), 157. 

B. A. Magnuson, N. Shirtliff and R. P. Bird, Resistance of aberrant crypt foci to apoptosis induced by azoxymethane in rats chronically fed cholic acid. Carcinogenesis, 1994, 15(7), 1459. 

Carcinogenesis inhibition. Decoction of the dried rhizome, in the ration of rats at a concentration of 20% of the diet, was equivocal vs azoxymethane-induced aberrant crypt focF . ... 

Caderni, G., Filippo, C.d., Luceri, C., Salvadori, M., Giannini, A., Biggeri, A., Remy, S., Cheynier, V., and Dolara, P., Effects of black tea, green tea and wine extracts on intestinal carcinogenesis induced by azoxymethane in F344 rats. Carcinogenesis, 21, 1965, 2000. 

The simple chalcone 70 has distributed widely in Glycyrrhizin plants as a minor constituent, and its glycosides are main flavonoids of licorice as described in Chapter 1. Recently, Okuyama et al. reported inhibition effect of the chalcone (70) on azoxymethane-induced murine colon aberrant crypt foucus formation and carcinogenesis [116]. 

Reddy, B.S., Narisawa, T., Wright, P, Vukusich, D., Weisburger, J.H. Wynder, E.L. (1975) Colon carcinogenesis with azoxymethane and dimethylhydrazine in germ-free rats. Cancer Res., 35, 287-290... 

Ju J, Liu Y, Hong J, Huang MT, Conney AH, Yang CS. 2003. Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse model. Nutr Cancer 46 172-178. 

Kwon Y, Magnuson BA. 2007. Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis. Scand J Gastroenterol 42 72-80. 

Fiber was shown to inhibit carcinogenicity of 2-acetylaminofluorene more than thirty years ago (7,17). A recent review (18) has pointed out the lack of consistency in studies of fiber effects on experimental colon carcinogenesis. Investigators use different strains of rat, stock or semipurified diets, and different carcinogens administered orally, subcutaneously or intrarec-tally (Table v). Ward et al. (19) found cellulose to have no effect on the carcinogenicity of azoxymethane (AOM) in male Fisher rats fed a semipurified diet. Freeman et al. (20), on the other hand, found cellulose to protect male Wistar rats from colon cancer induced by subcutaneous injection of 1,2-dimethylhydrazine (DMH). 

Continuous feeding of rats with 1% fenugreek seed powder (FSP) and 0.05% and 0.10% diosgenin suppressed total colonic aberrant crypt foci (ACF) by up to 32, 24 and 42%, respectively, in azoxymethane-induced carcinogenesis in rats. During the promotional stages, FSP inhibited total ACF. 

Rao, C.V., Simi, B., and Reddy, B.S., Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis (London), 14, 2219, 1993. 

Kawamori, T., Tanaka, T., Hirose, Y., Ohnishi, M. and Mori, H. 1996. Inhibitory effects of rf-limonene on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. Carcinogenesis. 17(2) 369—372. 

Ohkami, H., Tazawa, K., Yamashita, I., Shimizu, T., Murai, K., Kobashi, K. and Fujimaki, M. 1995. Effects of apple pectin on fecal bacterial enzymes in azoxymethane-induced rat colon carcinogenesis, Jpn. J. Cancer Res., 86(6) 523-529. 

Kohno H, Maeda M, Tanino M et al (2002) A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis. Cancer Lett 183 131-139... 

Sohn OS, Ishizaki El, Yang CS, et al. 1991. Metabohsm of azoxymethane, methylazoxymethanol and A-nitrosodimethylamine by cytochrome P450IIE1. Carcinogenesis 12 127-131. 

Rao CV, Tokomo K, KeUoff G, Reddy BS. Inhibition by dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats. Carcinogenesis 1991 12 1051-1055. 

Yang, K. et al., Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon. Carcinogenesis, 21,1655,2000. 

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