Sodium dextran sulfate

Tokuyama H, Ueha S, Kurachi M, et al. The simultaneous blockade of chemokine receptors CCR2, CCR5 and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis. Int Immunol 2005 17 1023-1034. 

Bertolotti, A., Wang, X., Novoa, I., Jungieis, R., Schlessinger, K., Cho, J.H., West, A.B. andRon, D. (2001) Increased sensitivity to dextran sodium sulfate colitis in IRE Ibeta-deficient mice. J. Clin. Invest. 107, 585-593. 

Gewirtz AT, Collier-Hyams LS, Young AN, Kucharzik T, Guilford WJ, Parkinson JF, Williams IR, Neish AS, Madara JL (2002) Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. J Immunol 168 5260-5267... 

Colitis 2% Dextran sodium sulfate in drinking water Reduction in severity of clinical symptoms of colitis. No change in the levels of CC chemokine production or leukocyte recruitment compared to wild type. Elevated IL-17 production from yb Tcells contributes to protection. 

The second example of what might be considered to be an unexpected D6 null phenotype came from our studies using the dextran sodium sulfate (DSS)-induced model of colitis [29]. D6 is abundantly expressed in the colon and upregulated during colitis in wildtype mice. However, we found that D6 null mice had a reduced tendency to develop the clinical symptoms of colitis compared to their wildtype counterparts, and had neither altered levels of bioavailable inflammatory CC chemokines nor... 

Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated cohtis lack of CC chemokine receptor 5 expression results in a NKl.l + lymphocyte-associated Th2-type immune response in the intestine. Journal oflmmundogy (Baltimore, Md 1950), 164, 6303-6312. 

Tanaka, T., Kohno, H., Suzuki, R., Yamada, Y, Sugie, S., and Mori, H. (2003) A novel inflanunation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci. 94, 965-973. 

Andres, P. G., Beck, P. L., Mizoguchi, E., Mizoguchi, A., Bhan, A. K., Dawson, T., Kuziel, W. A., Maeda, N., MacDermott, R. P., Podolsky, D. K., and Reinecker, H. C. (2000). Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis Lack of CC chemokine receptor 5 expression results in a NKl.l-i- lymphocyte-associated Th2-type immune response in the intestine. J. Immunol. 164, 6303-6312. 

Vidda, S., Vilaseca, J., Antolin, M. et al (2001) Dietary inulin improves distal colitis induced by dextran sodium sulfate in the rat. Am. J. Gastroenterol, 96,1486-1493. 

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