Collagen gene

Reported studies have shown its anti-inflammatory effects and anti-oxidant action. It acts by thinning the stratum corneum, promoting epidermolysis, dispersing basal layer melanin and epidermal and dermal hyaluronic acid and collagen gene expression that increases through an elevated secretion of IL-6 [3]. 

Genetic linkage to collagen genes has been shown for a few other conditions not listed here. 

Chojkier, M., Houghim, K., Solis-Hemizo, J. and Brenner, D.A. (1989). Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts A role for lipid peroxidation J. Biol. Chem. 264, 16957-16962. 

Zhang K, Rekhter MD, Gordon D, Phan SH. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohisto-chemical and in situ hybridization study. Am J Pathol 1994 145(1) 114-125. 

Koltai, H., Chejanovsky, N., Raccah, B. and Spiegel, Y. (1997) The first isolated collagen gene of the root-knot nematode Meloidogyne javanica is developmen-tally regulated. Gene 196, 191-199. 

Cox, G.N. (1990) Molecular biology of the cuticle collagen gene families of Caenorhabditis elegans and Haemonchus contortus. Acta Tropica 47, 269-281. 

Cox, G.N. and Hirsh, D. (1985) Stage-specific patterns of collagen gene-expression during development of Caenorhabditis elegans. Molecular and Cellular Biology 5, 363-372. 

Johnstone, I.L., Shaft, Y., Majeed, A. and Barry, J.D. (1996) Cuticular collagen genes from the parasitic nematode Ostertagia drcumcincta. Molecular and Biochemical Parasitology 80, 103-112. 

Jones, J.T., Curtis, R.H., Wightman, P.J. and Burrows, P.R. (1996) Isolation and characterization of a putative collagen gene from the potato cyst nematode Globodera pallida. Parasitology 113, 581—588. 

Kingston, B.I. (1991) Nematode collagen genes. Parasitology Today 7,11-15. 

Kingston, B.I., Wainwright, S.M. and Cooper, D. (1989) Comparison of collagen gene-sequences in Ascaris suum and Caenorhabditis elegans. Molecular and Biochemical Parasitology 37, 137-146. 

Park, Y.S. and Kramer, J.M. (1994) The C. elegcms sqt-1 and rol-6 collagen genes are coordinately expressed during development, but not at all stages that display mutant phenotypes. Developmental Biology 163, 112-124. 

Shamansky, M.L., Pratt, P., Boisvenue, R.J. and Cox, G.N. (1989) Cuticle collagen genes of Haemonchus contortus and Caenorhabditis ekgans are highly conserved. Mokcular and Biochemical Parasitology 37, 73—86. 

VonMende, N., Bird, D.M., Albert, P.S. and Riddle, D.L. (1988) dpy-13-a nematode collagen gene that affects body shape. Cell 55, 567-576. 

Vuorio, E. and DeCrombrugghe, B. (1990) The family of collagen genes. Annual Review of Biochemistry 59, 837-872. 

Stokes DG et al (2001) Regulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factors. Biochem J 360 (Pt 2) 461 170... 

Baer AE et al (2001) Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures. J Orthop Res 19(1) 2—10... 

Mouse models have been developed to analyze the biological function and molecular mechanisms of collagen proteins. In Table 1, the phenotypes of the mouse models of collagen genes and collagen biosynthesis-related proteins are briefly summarized. 

Mov13 mice carry a provirus that prevents transcription initiation of the a1(l) collagen gene. Mutant mice 49-51... 

V/XI collagen genes/" col5al, col5a3, and coll la2. Immunohistochemical analysis suggested that type XXVII collagen localizes at the ossification site of hypertrophic cartilage/ ... 

Osteogenesis imperfecta Mutations in collagen genes Skeletal deformities Fractures, blue sclera... 

Ehlers-Danlos syndromes Mutations in collagen genes and lysine hydroxylase gene Hyperextensible, fragile skin HypermobUe joints, dislocations, varicose veins, ecchymoses, arterial, intestinal ruptures... 

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