Cuticle collagens

Fig. 9.2. Cuticle collagen and morphological mutants of C. elegans. A selection of adult-stage C. elegans morphological mutants were analysed by scanning electron microscopy and compared with the wild-type N2 strain. Mutant alleles depicted are dpy, dumpy rot, roller Ion, long bli, blister. Scale bar represents...

The three Squat (sqt) mutants have a characteristic dominant-dumpy/ recessive-roller phenotype, and of the two genes characterized sqt-1 and sqt-3), both encode cuticle collagens (Kramer, 1997). 

Cuticle Collagen/Cuticulin Cross-linking Enzymes... 

Cox, G.N. (1990) Molecular biology of the cuticle collagen gene families of Caenorhabditis elegans and Haemonchus contortus. Acta Tropica 47, 269-281. 

Cox, G.N. (1992) Molecular and biochemical aspects of nematode cuticle collagens. Journal of Parasitology 78, 1-15. 

Fujimoto, D., Horiuchi, K. and Hirama, M. (1981) Isotrityrosine, a new crosslinking amino-acid isolated from Ascaris cuticle collagen. Biochemical and Biophysical Research Communications 99, 637-643. 

Johnstone, I.L. (1994) The cuticle of the nematode Caenorhabditis elegans - a complex collagen structure. BioEssays 16, 171-178. 

Shamansky, M.L., Pratt, P., Boisvenue, R.J. and Cox, G.N. (1989) Cuticle collagen genes of Haemonchus contortus and Caenorhabditis ekgans are highly conserved. Mokcular and Biochemical Parasitology 37, 73—86. 

Yang, J. and Kramer, J.M. (1994) In vitro mutagenesis of Caenorhabditis elegans cuticle collagens identifies a potential subtilisin-like protease cleavage site and demonstrates that carboxyl domain disulfide bonding is required for normal function but not assembly. Molecular and Cellular Biology 14, 2722-2730. 

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