Genetic linkage

Genetic linkage analyses have identified inherited human disorders due to abnormal function of K+... 

Genetic linkage to collagen genes has been shown for a few other conditions not listed here. 

Baron, M., Endicott, J. and Ott, J. (1990), Genetic linkage in mental illness , British Journal of Psychiatry, 157, 645-655. 

Genetic linkage to nicotine dependence was examined in families from New Zealand, and regions on chromosomes 2, 4, 10, 16, 17 and 18 yielded small but positive lod scores [39]. These findings were not replicated in a study on families from the United States. All these studies were relatively small and it is probable they did not provide sufficient power to detect genes of small effect or those which influence risk in only a proportion of the families. 

Bertram, L., Blacker, D., Mullin, K. etal. Evidence for genetic linkage of Alzheimer s disease to chromosome lOq. Science 290 2302-2303, 2000. 

Moffatt, M., Mill, M. and Cornells, F. (1994). Genetic linkage of T cell receptors and y/5 complex to specific IgE response, Lancet, 343, 1997-2001. 

Research into the risk factors for Cluster A personality disorders has focused on genetic factors. In particular, many researchers have looked for a shared genetic linkage between these disorders and schizophrenia. Only schizotypal personality appears to be genetically linked to schizophrenia. It may be that STPD exists on a biological continuum with schizophrenia. In other words, STPD could theoretically be a far milder variant of Axis I schizophrenia. There is less evidence linking PPD or SPD to schizophrenia nevertheless, certain characteristic symptoms of these other disorders also overlap with schizophrenia. 

Hamilton SP, Slager SL, Heiman GA, Haghighi F, Klein DF, Hodge SE, Weissman MM, Fyer AJ, Knowles JA (2000b) No genetic linkage or association between a functional promoter polymorphism in the monoamine oxidase-A gene and panic disorder. Mol Psychiatry 5 465-466... 

Stein MB, Chartier MJ, Kozak MV, King N, Kennedy JL (1998b) Genetic linkage to the serotonin transporter protein and 5HT2A receptor genes excluded in generalized social phobia. Psychiatry Res 81 283-291... 

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