Collagen gene expression

Reported studies have shown its anti-inflammatory effects and anti-oxidant action. It acts by thinning the stratum corneum, promoting epidermolysis, dispersing basal layer melanin and epidermal and dermal hyaluronic acid and collagen gene expression that increases through an elevated secretion of IL-6 [3]. 

Chojkier, M., Houghim, K., Solis-Hemizo, J. and Brenner, D.A. (1989). Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts A role for lipid peroxidation J. Biol. Chem. 264, 16957-16962. 

Zhang K, Rekhter MD, Gordon D, Phan SH. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohisto-chemical and in situ hybridization study. Am J Pathol 1994 145(1) 114-125. 

Cox, G.N. and Hirsh, D. (1985) Stage-specific patterns of collagen gene-expression during development of Caenorhabditis elegans. Molecular and Cellular Biology 5, 363-372. 

Stokes DG et al (2001) Regulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factors. Biochem J 360 (Pt 2) 461 170... 

Baer AE et al (2001) Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures. J Orthop Res 19(1) 2—10... 

It has been known for some years that ascorbic acid stimulates collagen gene expression and collagen synthesis in cultured fibroblasts [83] and, more recently, it has become clear that this effect is related to the ability of ascorbic acid to induce lipid peroxidation in the presence of iron ions, with the formation of reactive aldehydes [84],... 

Johnstone IL. Cnticle collagen genes. Expression in Caenorhabdi-tis elegans. Trends. Genet. 2000 16 21-27. 

Peltonen, J., Hsiao, L.L., Jaakkola, S. etal. (1991). Activation of collagen gene expression in keloids colocalization of Type I and VI collagen and transforming growth factor 1 mRNA. J. Invest. Dermatol. 97, 240-248. 

Shahzeidi, S., Mulier, B., de Crombru he, B., Jeffery, P.K., McAnulty, R.J. and Laurent, G.J. (1993). Enhanced type III collagen gene expression during bleomycin induced lung fibrosis. Thorax 48, 622-628. 

Verrecchia F, Mauviel A. TGF-p and TNF-a antagonistic cytokines controlhng type I collagen gene expression. Cellular Signalling 2004 16 873-80. 

Zangrilli, J. G., Mayeno, A. N., Vining, V., and Varga, J., l,l -Ethylidene-bis[L-tryptophan], an impurity in L-tryptophan associated with eosinophilia-myalgia syndrome, stimulates type I collagen gene expression in human fibroblasts in vitro, Biochem. Mol. Biol, bit., 37, 925, 1995. 

Varga J, Li L, Jimenez S (1993) Increased type I collagen gene expression in L-tryptophan associated eosinophilia-myalgia syndrome skin fibroblasts. J Rheumatol, 20 1303-1308. 

Chaquor, B., Bellon, G., Seite, S., Borel, J.P., and Four-tanier, A., All trans-retinoic acid enhances collagen gene expression in irradiated and non-irradiated hairless mouse skin, J. Photochem. Photobiol. B Biology, 37, 52-59, 1997. 

Kauh, Y.C., Rouda. S.. Mondragon, G., Tokarek, R.. Di Leonardo, M., liian, R.S., and Tan, EM. (1997) Major Suppression of Pro-Alpha 1 (I) IVpe Collagen Gene Expression in the Dermis After Keloid Excision and Immediate Intrawound Injection of Triamcinolone Acetonide, J. Am. Acad. Dermatol. 37, 586-589. 

Johnstone, I.L. Cuticle collagen genes. Expression in Cae-norhabditis elegans. Trends Genet. 2000, 16 (1), 2 1-27. 

Houglum, K., Brenner, D. A., and Chojkier, M., 1991b, d-alpha-tocopherol inhibits collagen alpha 1(1) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation, J. Clin. Invest. 87 2230-2235. 

I-dependent functions. Removal of these inhibitors by specific antibodies restores collagen gene expression. Therefore, vitamin C deficiency seems to induce the synthesis of inhibitors of IGF-dependent functions, such as collagen gene expression (Goldstein et ai, 1989 Peterkofsky et al., 1994 Gosiewska et al., 1994). 

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