Clinical score

While the treatment of infections can be of beneflt in COPD patients a Cochrane systematic review concludes that bronchodilators produce only modest short-term improvement in clinical scores in patients with bronchitis. This small beneflt must be weighed against the costs of these agents. 

Author Patient No. Duration Clinical scores of rhinitis Medical score Challenge IgE/IgG4 ratio... 

The intramuscular injection of naked pDNA has also been evaluated for therapy of EAE, a mouse model of multiple sclerosis. The disease is induced in mice by s.c. injection of myelin basic protein (MBP) or proteolipid protein (PLP). In a recent study, mice were injected i.m. with pDNA encoding either IL-4/IgG or TGF / 48 hours prior to each MBP injection (on days zero and seven) (Piccirillo and Prud -homme, 1999). The disease severity was 70% lower in the IL-4/IgG or TGF / -treated mice and the mean clinical scores were significantly reduced in both groups. In addition, the IL-4 and TGF -treated mice had significantly reduced CNS inflammation, reduced T cell proliferative responses to MBP and low levels of the Th 1 cytokines IL-12 and IFN7. Thus, the pDNA therapy appeared to shift the mice to a Th2 response, which was therapeutic and reduced the severity of the disease. 

Clinical Score Swelling and inflammation develop differently in the paws of... 

DBA/1 and C57BL/6 mice. Table 11.1 shows how clinical scores are assigned per mouse strain. The score is determined for all four paws. A maximal score of 4 can be reached per paw, resulting in a maximum total score of 16 per mouse (see Note 6). 

The clinical score better reflects the development of CIA in C57BL/6 mice than the caliper score. 

Morrow DA, Antman EM, Charlesworth A, et al. The TIMI risk score for ST elevation myocardial infarction a convenient bedside clinical score for risk assessment at presentation. Circulation 2000 102 203 I -2037. 

Serup, J. A double-blind comparison of two creams containing urea as the active ingredient. Assessment of efficacy and side-effects by non-invasive techniques and a clinical scoring scheme. Acta Derm. Venereol. (Stockh.) 1992 177 (Suppl.) 34-43. 

Dietary supplementation studies with n-3 fatty acids alone have generally not been promising in atopic dermatitis. An initial double-blind study reported a subjective improvement on fish oil compared with the control OA, but no objective improvement on physician assessment.179 A further double-blind study using EPA with saturated fatty acids as the control, showed equal improvement with both supplements and the benefit was attributed to increased clinician guidance,180 while a multicenter study showed a similar improvement in clinical score in subjects taking fish oil or corn oil.181 The latter results might possibly reflect a beneficial effect of both EFA-containing oils, but more likely imply a placebo effect, and illustrate the problems posed both in selection of a suitable control and the interpretation of such studies. 

Serup, J., EEMCO Guidance for the assessment of dry skin (xerosis) and ichthyosis clinical scoring systems. Skin Res. Technol. 1 109-114, 1995. 

Van Neste, D. and de Brouwer, B., Monitoring of skin response to sodium lauryl sulfate clinical scores versus bioengineering methods, Contact Dermatitis, 27, 151-156, 1992. 

There are observations that milk whey formula supplemented with L. rhamnosus (strain GG) could alleviate some aspects of atopy and intestinal inflammation among infants with atopic eczema or food allergy. Furthermore, clinical scores of the eczema were reduced in breast-fed infants whose mothers consumed Lb-GG. 

Laurent A, Garcia-Larrea L, d Amato T, Bosson JL, Saoud M, et al. 1999. Auditory event-related potentials and clinical scores in unmedicated schizophrenic patients. Psychiatry Res 86 229-238. 

Hawkins GC, Bonita R, Broad JB et al. (1995). Inadequacy of clinical scoring systems to differentiate stroke subtypes in population-based studies. Stroke 26 1338-1342 Hjort N, Christensen S, Soiling C et al. (2005a). Ischemic injury detected by diffusion imaging 11 minutes after stroke. Annals of Neurology 58 462-465... 

ThakarCV, Arrigain S, Worley S,Yared JP, Paganini EP A clinical score to predict acute renalfailureaftercardiacsurgery. J Am Soc Nephrol. 2005 16 162-168... 

Noseworthy JH. Clinical scoring methods for multiple sclerosis. Ann Neurol 1994 36 S80-S85. 

Zulewski H, Muller B, Exer P, et al. Estimation of tissue hypothyroidism by a new clinical score Evaluation of patients with various grades of hypothyroidism and controls. J Clin Endocrinol Metab 1997 82 771-776. 

Kane, 1., et al., Comparison of 10 different magnetic resonance perfusion imaging processing methods in acute ischemic stroke effect on lesion size, proportion of patients with diffusion/perfusion mismatch, clinical scores, and radiologic outcomes. Stroke, 2007. 38(12) p. 3158-64. 

Day of the experiment Clinical scoring Throat swab Blood withdrawal Nasal wash Saliva... 

Throat swabs, blood withdrawals, nasal washes and saliva samples are isolated on the indicated (X) days. Blood specimens (3 mL) are taken by venipuncture from the cephalic vein. Nasal washes are collected by instilling 1.5 mL of sterile phosphate-buffered saline (PBS) into the nostril and immediately aspirating wash fluid and secretions with a sterile S5uinge. Saliva specimens are collected by aspiration from the cheek pouch. Prior to throat swabbing, clinical scoring of tonsillitis and pharyngeal erythema severity is performed by a trained veterinarian who is blinded to the two animal groups. 

Perform day-0 sample isolations and clinical scorings as outlined in Table 1 and Subheading 4.4. 

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