Proteolipid protein

PLP Proteolipid protein PLT Primed lymphocyte typing PMA Phorbol myristate acetate PMC Peritoneal mast cell PMN Polymorphonuclear neutrophil... 

DPDPB has been used to study the endocytosis of cadherin from intracellular junctions (Troyanovsky et al., 2006), the subunit arrangement in the flagellar rotor assembly (Lowder et al., 2005), and the disease-associated mutations in myelin proteolipid protein in the endoplasmic reticulum (ER) (Swanton et al., 2005). DPDPB can be used to conjugate reduced antibody molecules to p-D-galactosidase using essentially the same protocol as that described by O Sullivan et al. (1979). 

Swanton, E., Holland, A., High, S., and Woodman, P. (2005) Disease-associated mutations cause premature oligomerization of myelin proteolipid protein in the endoplasmic reticulum. PNAS 102, 4342-4347. 

Jimpy mouse, rumpshaker mouse, myelin-deficient (md) rat, shaking dog X-linked Proteolipid protein (PLP) Variable degrees of oligodendrocyte death and CNS myelin deficiency, decreased spacing at intraperiod line of compact CNS myelin see text 1,9,10,43,44... 

Greer, J. M. and Lees, M. B. Myelin proteolipid protein-the first 50 years. Int. J. Biochem. Cell. Biol. 34, 211-215,2002. 

Hudson, L. D. Proteolipid protein gene. In R. A. Lazzarini (ed.), Myelin biology and disorders. San Diego, CA Elsevier Academic Press, 2004,401-420. 

Stecca, B., Southwood, C. M., Gragerov, A. et al. The evolution of lipophilin genes from invertebrates to tetrapods DM-20 cannot replace proteolipid protein in CNS myelin. /. Neurosci. 20,4002-4010, 2000. 

Gudz, T. I., Schneider, T. E., Haas, T. A. et al. Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes. /. Neurosci. 22,7398-7407, 2002. 

Another, but less well defined, class of molecules, some of whose members mediate adhesion interaction, is the four-transmembrane domain family, which shares similar hydropathy plots and may have similar dispositions with respect to the phospholipid bilayer, for example the myelin proteolipid proteins, the connexins of gap junctions, the ryanodine receptor and others. 

In the CNS of mammals, two proteins are needed to accomplish the dual role of adhesion at both myelin bilayer surfaces that P0 effects in the PNS. The four-trans-membrane-domain proteolipid protein (PLP) is likely to be responsible for adhesion of the extracellular surfaces, while the very basic cytoplasmic myelin basic protein... 

Kalwy, S. A. and Smith, R. Mechanisms of myelin basic protein and proteolipid protein targeting in oligodendrocytes. Mol. Membr. Biol. 11 67-78,1994. 

PLP proteolipid protein SCHAD short chain 3-hydroxyacyl-CoA dehydrogenase... 

The most hydrophobic integral membrane proteins can be extracted into organic solvents such as mixtures of chloroform and methanol. One such proteolipid protein, the 23.5-kDa lipophilin, accounts for over half the protein of myelin.57 182 The purified protein from rat brain contains 66% of nonpolar amino acids and six molecules of covalently bound palmitic acid and other fatty acids per peptide chain in thioester linkage to cysteine side chains. This protein evidently has four transmembrane helical segments with the six fatty acid chains incorporated into the membrane bilayer. It also has cytoplasmic and extracellular loops, one of which binds inositol hexakisphosphate (Ins P-6). (Fig. 11-9).183 The myelin proteolipid is an essential component of the myelin sheath and defects in this protein are associated with some demyelinating diseases57 which are discussed in Chapter 30. 

The intramuscular injection of naked pDNA has also been evaluated for therapy of EAE, a mouse model of multiple sclerosis. The disease is induced in mice by s.c. injection of myelin basic protein (MBP) or proteolipid protein (PLP). In a recent study, mice were injected i.m. with pDNA encoding either IL-4/IgG or TGF / 48 hours prior to each MBP injection (on days zero and seven) (Piccirillo and Prud -homme, 1999). The disease severity was 70% lower in the IL-4/IgG or TGF / -treated mice and the mean clinical scores were significantly reduced in both groups. In addition, the IL-4 and TGF -treated mice had significantly reduced CNS inflammation, reduced T cell proliferative responses to MBP and low levels of the Th 1 cytokines IL-12 and IFN7. Thus, the pDNA therapy appeared to shift the mice to a Th2 response, which was therapeutic and reduced the severity of the disease. 

Major myelin proteolipid proteins, PLP and DM-20. In 1951 Folch and Lees discovered that a substantial amount of proteins from brain white matter could be... 

Knapp PE (1996) Proteolipid protein Is it more than just a structural component of myelin Dev Neurosci 18 297—308. 

McRae BE, Kennedy MK, Tan LJ, Dal Canto MC, Piclia KS, Miller SD (1992) Inducdon of acdve and adopdve relapsing experimental autoimmune enceplialomyelids (EAE) using an enceplialitogenic epitope of proteolipid protein. J Neuroimmunol 38 229—240. 

PLP refers to proteolipid protein that is present in myelin. 

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