Ageing population, clinical research

Abernethy, DR. Research challenges, new drug development, prechnical and clinical trials in the ageing population. Drug Safety 1990 5 71. ... 

Nevertheless, at least six randomized, double-blind, placebo-controlled, intervention trials have assessed the effect of vitamin or micronutrient supplements on AMD risk. The consensus from these and other trials seems to suggest a positive response of the retina as well as improved visual performance from vitamin and mineral supplementation such as the AREDS formulation (see above). Specifically, the AREDS results should be interpreted as understanding that the formulation was effective in slowing the risk of progression of AMD in persons 55 years of age and older who had some macular changes consistent with early age-related maculopathy. More recently, substantiation of these results was reported on a primarily white population as part of the Rotterdam Study. An above-median intake of beta-carotene, vitamin C, vitamin E, and zinc was associated with a 35% reduced risk of AMD. Still other clinical research has demonstrated shortterm beneficial effects in small populations for lutein and a combination of lutein and antioxidants in AMD. 

A clinical research team followed up aU deaths reported to VAERS most of these deaths were ultimately classified as SIDS analysis of the age distribution and seasonality of infant deaths reported to VAERS showed that they matched the age distribution and seasonality of SIDS both peaked at 2-4 months and during the winter the reduction in the number of deaths reported to VAERS since 1992-93 parallels the overall reduction in the incidence of SIDS in the US population since the implementation of the Back to sleep campaign the Food and Drug Administration (FDA) and the Institute of Medicine (lOM) reviewed 206 deaths reported to VAERS during 1990-91 only one death was believed to have resulted from a vaccine. 

The growth of the aging population, regulatory overview and increased business opportunities will ensure the growth of clinical research in the elderly. Recent reports of the high level of seniors adverse events, many leading to deaths, both in and... 

Most BME research is located in universities, often in collaboration with clinical groups in teaching hospitals. Major research areas include prostheses, non-invasive measurement, biomechanics, and - most appropriately in a country of such vast distances and with an ageing population - rehabilitation, telemedicine, and home healthcare monitoring. 

Patient Population. The proband of the B family, T.B., was referred to the Lipid Research Clinic at The Johns Hopkins Hospital at the age of five years because of hypercholesterolemia of 900 mg/100 ml. She had multiple planar xanthomas that had first appeared at three years of age. The patient was free of symptoms of ischemic heart disease. The index lipoprotein pattern was type lib (57), with marked hypercholesterolemia, hyperbeta-lipoproteinemia, a mild hyperprebetalipoproteinemia and hypertriglyceridemia. None of the relatives of T.B. had xanthomas or corneal arcus one (J.S.) developed signs of premature coronary atherosclerosis at the age of 43 years. Increased total plasma and LDL cholesterol levels were transmitted over three generations on both maternal and paternal sides of the family (Fig. I). The parents of the proband, S.B. and K.B., had endogenous hypertriglyceridemia as well. Two normolipidemic members of this family (S.B., Jr. and E.B.), were also studied. 

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