Cancer clinical research

In the case of cancer, that is, advanced or metastasized cancer, a recommendation is that cancer clinical research centers, or CCRCs, be set up in new or existing facilities, as previously indicated. These would comprise a nationwide network, even worldwide, and would be staffed by M.D.s and D.O.s commonly supported by a variety of pharmacologists, botanists, herbalists, etc., who are familiar with the world of plants and plant medicines, the main source for alternatives. In a way, the Cancer Treatment Centers of America tend to fill this function at least partially, although there are only three locations, in the Chicago area, in Tulsa, and in Seattle. Both conventional and CAM therapies are offered, at the patient s discretion. It may be mentioned in passing that the CTCA no longer speaks of cures but of treatments, after they ran into trouble with the Federal Trade Commission (FTC) back in 1996. 

In the conrse of the work, the NCI decided on plans for nsing intermediate markers or indicators for the conrse of genetic, biochemical, and immnnologic fnnctions. This avoids the long waiting period for incipient cancers to grow. (Even more decisive wonld be a protocol of chnical tests for patients already snffering with cancer, for example, in cancer clinical research centers.)... 

For the reasons mentioned previously, in whole or in part, it is recommended that widespread and convenient cancer clinical research centers (CCRC) or their... 

We note that Dr. Horrobin s philosophy agrees with the concept of creating a countrywide network of cancer clinical research centers, or CCRCs, as previously noted. Dr. Horrobin was also cited in Part 2 of Marcus Cohen s articles on medical censorship.)... 

It is added by Dr. Nair that eight out of ten cancer patients now use some form of complementary and alternative medicine (CAM), mostly in conjunction with conventional medical treatments. (This, in comment, should supposedly lead to a significant decrease in cancer-related deaths.) Moreover, the use of Haelan 951 can apparently serve as an adjuvant in conjimction with conventional chemotherapy. Whereas thousands of patients in the United States, Europe, and Asia have been taking Haelan 951 as an adjunct or stand-alone treatment for cancer, most of the clinical trials have been conducted at medical and research institutions in China. More such clinical research is called for in the United States. (This is most likely, given the prevailing mind-set of the medical establishment. However, the creation of cancer clinical research centers [CCRCs] would fulfill this need, as described elsewhere.)... 

Lastly, the ultimate word is always that of clinical successes, and for this reason it is advocated that a network of cancer clinical research centers (CCRCs) be instituted — or the equivalent — to serve initially as a court of last resort for advanced or terminal cancer cases, and later on for any case. These would be primarily staffed by M.D.s and D.O.s, and backed by a system of supportive pharmacologists, biochemists, botanists and ethnobotanists, biologists and zoologists, plus assorted naturopaths and the like — even if considered unconventional, but which are possibly a vital link in the therapeutic chain. 

Identification and validation of biomarkers predictive of disease, particularly cancer, is a significant and expanding area in clinical research. Quality cancer biomarkers should facilitate early detection and diagnosis of the disease, with more specific markers used for classification (such as grade/stage) or subtype determination of the... 

Issa, J.P. (2007) DNA mefhylation as a therapeutic target in cancer. Clinical Cancer Research, 13, 1634—1637. 

Kirn D. Clinical research results with dll520 (Onyz-015), a replication-selective adenovirus for the treatment of cancer What have we learned Gene Therapy 2001 8 89-98. 

Andre T, de Gramont A, Study Group of Clinical Research in Radiotherapies Oncology, Oncology Multi-diciplinary Research Group. An overview of adjuvant systemic chemotherapy for colon cancer. Clin Colorectal Cancer. 2004 4(suppl 1) S22—S28. 

Several U.S. researchers speculate that the authors of the French report mistakenly drew their conclusion from published studies analyzing naturally occurring creatine found in protein-rich animal products such as beef and pork. When these creatine-containing foods are heated and cooked, the creatine and amino acids interact to form compounds known as heterocyclic amines (HCAs), which have been shown to cause cancer in animal studies. The level of HCAs can vary with cooking method and other factors. Creatine monohydrate does not contain HCAs, and as of early 2002, no published or reported clinical research existed to demonstrate that creatine monohydrate taken in supplement form causes cancer. 

Mendelson J. 2000. Blockade of receptors for growth factors an anticancer therapy - the fourth annual Joseph H Burchenal American Association of Cancer Research Clinical Research Award Lecture. Clin Cancer Res 6 747-753. 

The cryptophycins (e.g. 16) form a group of depsipeptide antibiotics with a (R)-/7-AiB (R)-2 or / -Ala 1 substructure. They have already been isolated from cyanobacteria (Nostoc sp., see below) [47] arenastatin A 17 has been isolated from a marine sponge [42]. The cryptophycins are new lead structures within cancer drug research for their potent tumor-selective cytotoxicity [92]. The synthetic analog cryptophycin-52 (= 6-methylcryptophycin-l, LY-355703, 18) has reached clinical phase II trials [93]. 

Associate Director for Clinical Research Greenebaum Cancer Center University of Maryland Baltimore, MD 21201-1595... 

C.S.H. is a Cancer Research Campaign (UK) Clinical Research Fellow and holds ajunior Research Fellowship at Green College, Oxford. This work was supported by grants from the CRC (UK) to J. O D. M. G. 

For more on the interpretive flexibility built into clinical research, see Richards, Vitamin C and Cancer Epstein, Impure Science Marks, Progress of Experiment Marks, "Notes from the Underground. ... 

The research program at NIH also uses pharmacists in many of its 14 institutes. Pharmacists in the National Cancer Institute s (NCI s) Pharmaceutical Management Branch are involved in anticancer drug development, protocol development, collection of clinical data, distribution of NCI investigational drugs and the Treatment Referral Center. In addition, the intramural program of the NCI has a pharmacokinetics laboratory where pharmacists perform basic and clinical research. The National Institute of Allergy and Infectious Diseases (NIAID) Division of AIDS pharmacists participate in protocol development and implementation, and act as consultants to more than 300 pharmacists involved in NIAID-sponsored AIDS clinical trials. 

Patient participation in clinical research trials is a significant component of cancer care therapy, particularly... 

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