Cholesterol effects

Lindahl, B., Johansson, I., Huhtasaari, F., Hallmans, G., Asplund, K., Coffee drinking and blood cholesterol - effects of brewing method, food intake and life style. J Internal Medicine, 230, 299, 1991... 

Starke-Peterkovic T, Turner N, Vitha MF et al (2006) Cholesterol effect on the dipole potential of lipid membranes. Biophys J 90 4060-4070... 

Tu, K. Klein, M. Tobias, D. J., Constant-pressure molecular dynamics investigations of cholesterol effects in a dipalmitoylphosphatidylchohne bilayer, Biophys. J. 1998, 75, 2147-2156. 

The water-soluble methyl-P-cyclodextrin (mpCD) is known to form soluble inclusion complexes with cholesterol, leading to depletion of cholesterol from the plasma membrane (16,46,47). As a result, cholesterol-rich microdomains, which are involved in caveolae-mediated as well as clathrin-mediated endocytosis, are destroyed. mpCD therefore decreases both clathrin- and caveolae-mediated uptake. The two other well-known cyclodextrins [a-, and y-cyclodextrin (6 and 8 units of a-1,4 glucose)] do not bind cholesterol effectively (both are not specific for cholesterol, but might remove phospholipids from the plasma membrane) and have no significant effect (46). 

Carrol, R.M. and Rudel, L.L. 1981. Dietary fat and cholesterol effects on lipoprotein cholesterol ester formation via lecithin-cholestrol acyltrans-ferase (LCAT) in vervet monkey. J. Lipid Res. 22 359-363. 

Cholesterol substitutes and evolution of biosynthetic pathways leading to cholesterol. In their review of cholesterol effects on membranes, Robertson and Hazel (1997) outline a broad evolutionary picture in which the origins and the functional roles of cholesterol substitutes and bilayer-spanning membrane stabilizers in bacteria, Archaea, and plants are presented. Figure 7.28 portrays the types of molecules that serve as membrane stabilizers in these different taxa rigid hemilayer inserts, which have a cholesterol-like chemistry and membrane localization rigid bilayer inserts, which extend... 

M. koenigii (Linn), commonly known as the curry leaf plant, is highly valued for its characteristic aroma and medicinal properties. Its leaves are used extensively for culinary purposes, especially in curries and chut-neys, but also in vegetable, fish and meat dishes, pickles, buttermilk preparations, curry powder blends, etc. The major volatile components in curry leaf are a-pinene, 3-caryophyllene, (Ii)-P-ocimene, linalool and P-phellandrene. M. koenigii is a rich source of carbazole alkaloids. Its leaves, roots and bark are a tonic, stomachic and carminative. It is shown to possess a hypo-cholesterol effect and many other health benefits. The crop promises great scope in various biochemical and industrial applications in the future. 

Because of the blood lowering cholesterol effects of a manganese deficiency, involvement of manganese in lipid metabolism has been a topic of research interest as reviewed by Johnson and Kies in this volume. 

Cholesterol effects. The red line on the following graph shows the fluidity of the fatty acids of a phospholipid bilayer as a function of temperature. The blue line shows the fluidity in the presence of cholesterol. 

Carbohydrates and Atherosclerosis Food Choices in Everydav Living Mechanism of the Influence of Dietary Patty Adds on LDL- Cholesterol Effect of Drugs... 

The constituents of garlic bulbs, in particular the sulphur derivatives such as alliin, ajoenes, vinyldithines etc., are known for their lipid and cholesterol effects as well as antithrombotic... 

Cholesterol effect. Natural biological membranes consist of lipid bilayers, which typically comprise a complex mixture of phospholipids and sterol, along with embedded or surface associated proteins. The sterol cholesterol is an important component of animal cell membranes, which may consist of up to 50 mol% cholesterol. Cholesterol thickens a liquid-crystalline bilayer and increases the packing density of lipid acyl chains in the plane of the bilayer in a way that has been referred to as a "condensing effect". Increasing cholesterol concentration leads to a drastic reduction of the main transition enthalpy, A// , until at cholesterol contents higher than 30 - 50 mol% the main transition vanishes. 

Comments Compounds in this mushroom have anti-cholesterol effects. Chihara (1979) reported that lentinan, a water soluble polysacharide in L- edodes. was found to almost completely regress the solid type tumors of sarcoma-180 and several kind (sic) of tumors.. . The work of others (Cochran, 1978 Tokita et al., 1972 Tokuda and Kaneda, 1979) have similarly described the beneficial properties of this fungus. (See Appendix 111). 

Messinger WJ, Samet CM. The effect of a bowel sterilizii antibiotic cn blood coagulation mechanisms. The anti-cholesterol effect of paromomycin. Angiology (1965) 16, -36. 

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