Anti-cholesterol

Pravastatin 4 Pravastatin Anti-cholesterol Hydroxylation Streptomyces carbophilus Single-stage fermentation [5]... 

The blockbuster anti-cholesterol agents Lipitor (atorvastatin) and Crestors ... 

Anti-cholesterol drugs help arteries dilate, 20 July 1998 www.healthcentral.com/news... 

Ezetlmlbe Zetla, Vytorin (with simvastatin) Anti-cholesterol 25434... 

Comments Compounds in this mushroom have anti-cholesterol effects. Chihara (1979) reported that lentinan, a water soluble polysacharide in L- edodes. was found to almost completely regress the solid type tumors of sarcoma-180 and several kind (sic) of tumors.. . The work of others (Cochran, 1978 Tokita et al., 1972 Tokuda and Kaneda, 1979) have similarly described the beneficial properties of this fungus. (See Appendix 111). 

Messinger WJ, Samet CM. The effect of a bowel sterilizii antibiotic cn blood coagulation mechanisms. The anti-cholesterol effect of paromomycin. Angiology (1965) 16, -36. 

Xylan also has drawn considerable interest due to its potential for packaging films and coating food, as well as for its use in biomedical products [28]. Because it is referred to as a corn fiber gum with a sticky behavior, xylan has been used as an antithrombotic activity, adhesive, drug delivery system, anti-cholesterol, thickener, and additive to plastics [2, 7, 9,13, 36,44, 45]. 

These phosphoUpids have the property of inhibiting the final stages of cholesterol biosynthesis in human liver cells, and could be used as anti-cholesterol drugs. The most active compound is the last LPC shown in Figure 19.42, with an IC50 of 21pgml (Shin et al, 1999). These derivatives are also cytotoxic to a variety of types of cancer (lung, ovary, skin and colon) (Alam et al, 2001). 

Anti-nephritis activity and anti-nephrosis activity Hypoglycemic activity Cholesterol decreasing effect... 

Probucol, another di-r-butyl phenol, is an anti-atherosclerotic agent that can suppress the oxidation of low-density lipoprotein (LDL) in addition to lowering cholesterol levels. The antioxidant activity of probucol was measured, using EPR, with oxidation of methyl linoleate that was encapsulated in liposomal membranes or dissolved in hexane. Probucol suppressed ffee-radical-mediated oxidation. Its antioxidant activity was 17-fold less than that of tocopherol. This difference was less in liposomes than in hexane solution. Probucol suppressed the oxidation of LDL as efficiently as tocopherol. This work implies that physical factors as well as chemical reactivity are important in determining overall lipid peroxidation inhibition activity (Gotoh et al., 1992). 

LT4 is indicated for patients with overt hypothyroidism.22 However, the need for treatment is controversial in patients with mild or subclinical disease (TSH less than 10 milli-units/L). There are no large clinical trials that show an outcome benefit with treating these patients, and the therapeutic decision must be individualized.1,23 Many patients with subclinical hypothyroidism do, in fact, have subtle symptoms that improve with LT4 replacement. If the patient s serum cholesterol is elevated,24 or if serum anti-TPOAbs are present, many clinicians recommend LT4 therapy. 

Consider replacement therapy in patients with a TSH level of greater than 2.5 but less than 10 milliunits/L who have subtle symptoms (e.g., mild fatigue, lethargy, etc.), elevated cholesterol, or positive anti-TPOAbs. 

The first study was conducted to determine whether carotenoids and cholesterol share common pathways (transporters) for their intestinal absorption (During et al., 2005). Differentiated Caco-2 cells on membranes were incubated (16 h) with a carotenoid (1 pmol/L) with or without ezetimibe (EZ Zetia, an inhibitor of cholesterol transport), and with or without antibodies against the receptors, cluster determinant 36 (CD36) and scavenger receptor class B, type I (SR-BI). Carotenoid transport in Caco-2 cells (cellular uptake + secretion) was decreased by EZ (lOmg/L) as follows P-C and a-C (50% inhibition) P-cryptoxanthin and LYC (20%) LUT ZEA (1 1) (7%). EZ reduced cholesterol transport by 31%, but not retinol transport. P-Carotene transport was also inhibited by anti-SR-BI, but not by anti-CD36. The inhibitory effects of EZ and anti-SR-BI on P-C transport... 

Ajoene has antitumor activity, inhibits cholesterol biosynthesis, modulates membrane-dependent functions of immune cells, inhibits protein prenylation83 and is an anti-leukaemia agent for acute myeloid leukaemia.85 In antithrombotic assays, the Z isomer is more active than the E isomer.84... 

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