Chloride salicylic acid

O -(p-Aminobenzenesu I fonam idol pyridine Sodium nitrite Hydrogen chloride Salicylic acid... 

Oils Edible Safflower Potassium Binoxalate Ammonium Chloride Salicylic Acid Ammonium Chloride Lead Acetate Potassium Binoxalate Sodium Silicofluoride Ammonium Carbonate Fluocilicic Acid P-Dichlorobenzene Ammonium Phosphate Sec-Butyl Acetate Sec-Butyl Alcohol Calcium Phosphate Selenium Trioxide Selenium Dioxide Selenium Dioxide Selenium Dioxide Selenium Trioxide Antimony Trioxide Calcium Hypochlorite Carbaryl Cyclohexanone Charcoal... 

Oils Edible Safflower Potassium Binoxalate Ammonium Chloride Salicylic Acid Ammonium Chloride Lead Acetate Potassium Binoxalate Sodium Silicofluoride Ammonium Carbonate Fluocilicic Acid P-Dichlorobenzene... 

Safflower oil. See Safflower (Carthamus tinctorius) oil Safflower oil, hybrid. See Hybrid safflower (Carthamus tinctorius) oil Safflower oil monoglyceride. See Safflower glyceride Safflower oil (unhydrogenated) Safflower seed oil. See Safflower (Carthamus tinctorius) oil Sago starch. See Starch SAIB. See Sucrose acetate isobutyrate Sal ammonia Sal ammoniac. See Ammonium chloride Salicylic acid-2-ethylhexyl ester. See 2-Ethylhexyl salicylate Salicylic acid octyl ester. See Octyl salicylate Salicylsulfonic acid. See 5-Sulfosalicylic acid Saline. See Sodium chloride Salmiac. See Ammonium chloride SALP. See Sodium aluminum phosphate acidic Sal soda. See Sodium carbonate Salt. See Sodium chloride Sal tartar. See Sodium tartrate Salt cake. See Sodium sulfate... 

Required Salicylic acid, 10 g. pyridine, 7 ml. acetyl chloride. 

Dissolve 10 g. of salicylic acid (o-hydroxybenzoic acid) in 7 ml. of dry pyridine contained in a too ml. conical flask. Then without delay (since this solution if allowed to stand tends to become a semi-solid mass) run in 7 5 ml. (8 3 g.) of acetyl chloride, adding about i ml. of the chloride at a time, and shaking the mixture continuously during the addition. The heat of the reaction causes the temperature of the mixture to rise rapidly ... 

Reactions of Aspirin, (i) Distinction from Salicylic acid. Shake up with water in two clean test-tubes a few crystals of a) salicylic acid, (0) aspirin, a very dilute aqueous solution of each substance being thus obtained. Note that the addition of i drop of ferric chloride solution to (a) gives an immediate purple coloration, due to the free —OH group, whereas (b) gives no coloration if the aspirin is pure. 

However, this method is appHed only when esterification cannot be effected by the usual acid—alcohol reaction because of the higher cost of the anhydrides. The production of cellulose acetate (see Fibers, cellulose esters), phenyl acetate (used in acetaminophen production), and aspirin (acetylsahcyhc acid) (see Salicylic acid) are examples of the large-scale use of acetic anhydride. The speed of acylation is greatiy increased by the use of catalysts (68) such as sulfuric acid, perchloric acid, trifluoroacetic acid, phosphoms pentoxide, 2inc chloride, ferric chloride, sodium acetate, and tertiary amines, eg, 4-dimethylaminopyridine. 

Finally, attachment of a rather complex side chain to the para position of the benzene ring on the sulfonamide leads to the very potent, long-acting oral antidiabetic agent, glyburide (215). Preparation of this compound starts with the chlorosul-fonation of the acetamide of 3-phenethylamine (209). The resulting sulfonyl chloride (210) is then converted to the sulfonamide (211) and deacylated (212). Reaction with the salicylic acid derivative, 213, in the presence of carbodiimide affords the amide, 214. Condensation of that with cyclohexylisocyanate affords glyburide (215). ... 

Coumarin, or extract of Tonka beans, which contain coumarin, may be detected as follows A small quantity of the essence is evaporated to dryness, the residue fused with caustic potash, saturated with hydrochloric acid and treated with a drop of ferric chloride solution. If coumarin be present, a violet colour due to the formation of salicylic acid, will be produced. 

A method of preparation is to react an acid salt of choline (such as choline chloride or choline bromide) with an alkaline salt of salicylic acid (such as sodium salicylate, potassium salicylate, or magnesium salicylate) in an alcoholic media. 

Xanthone (Coll. Vol. i, 537) In nearly quantitative yields by distillation in vacuo of the acid chloride formed by the action of thionyl chloride on the phenyl ether of salicylic acid. Lock and Kempter, Monatsh. 67, 24 (1936). 

Quinoline Salicylic acid Silicon Dinitrogen tetroxide, linseed oil, maleic anhydride, thionyl chloride Iodine, iron salts, lead acetate Alkali carbonates, calcium, chlorine, cobalt(II) fluoride, manganese trifluoride, oxidants, silver fluoride, sodium-potassium alloy... 

As mentioned in the historical synopsis (Section 5.1), Levine121 perfected the compendial partition column procedure in which aspirin in chloroform is first trapped in an immobile phase of sodium bicarbonate on a column of siliceous earth (celite) then eluted with a solution of acetic acid in chloroform and measured spectrophotometrically. This has been also used for separation in combination products.80 For the determination of salicylic acid in presence of aspirin by this method, see Section 5.61. Ion exchange columns filled with strongly or weakly basic anion exchange resin in the acetate or chloride cycle have also been used for separation of aspirin in combination products. 122 123/l2lf This has also been adapted for a student experiment.125 A Sepha-dex-G25 column has been used for the separation of aspirin from salicylic acid.126... 

As has already been pointed out, the determination of salicylic acid is intricately interwoven with that of aspirin itself. There is the convenient color reaction with ferric chloride which was already used by Dreser1 to determine free salicylic acid in his own urine after the ingestion of aspirin. However, this reaction is not too specific and considerable work has gone in the development of interference free methods. 

A relatively uncontrolled attempt to enhance the colour yield and fastness to washing of selected direct dyes involved addition to the dyebath of a colourless reactant that was intended to form covalent attachments between these dyes and hydroxy groups in cellulose [135]. Most of the dyes selected contained at least two primary amino groups in aminonaphthol residues. The reactants evaluated were cyanuric chloride (7.3), N,N-diethyl-3-hydroxyazetidinium chloride (7.124) and 2,4-dichloro-6-(4,-sulphoanilino)-s-triazine (7.125), all of which will indeed react readily with primary arylamines. Some of the dyes selected, however, contained only diphenylurea or salicylic acid residues and these are most unlikely to react efficiently under dyeing conditions. 

In view of the well-known pharmacological action of aspirin, it was thought that the fluorine analogue, O (fluoroacetyl) salicylic acid, might be of considerable interest. The compound was readily made by acylation of salicylic acid by fluoroacetyl chloride in the presence of pyridine. The l.d. 50 for subcutaneous injection into mice was approximately 15 mg./kg. After injection the mice went into a drugged sleep, and died overnight. 

Experiment.—A few drops of ferric chloride solution are added to an aqueous solution of salicylic acid. The colour reaction characteristic of phenols is obtained. 

The reaction with carboxylic acid and acid anhydride is carried out in the presence of a small amount of concentrated sulphuric acid. The reaction is reversible, and therefore, water is removed as soon as it is formed. The reaction with acid chloride is carried out in the presence of a base (pyridine) so as to neutralise HCl which is formed during the reaction. It shifts the equilibrium to the right hand side. The introduction of acetyl (CH3CO) group in alcohols or phenols is known as acetylation. Acetylation of salicylic acid produces aspirin. 

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