Chemopreventive potential

Liu, Y.-L. et al., Dasytrichone, a novel flavone from Dasymaschalon trichophorum with cancer chemopreventive potential, Nat. Prod. Lett., 161, 1992. 

The hydroxylation of limonene affected its chemopreventive potential. The hydroxylated forms carveol, uroterpenol and sobrerol decreased tumour yield, sobrerol being the most potent. These monoterpenes were reported as cancer chemopreventive agents with little or no toxicity [292]. Also, carveol showed chemoprentive activity against carcinogens [293]. 

Surh, Y.J. and Lee, S.S. Capsaicin, a double-edged sword toxicity, metabolism, and chemopreventive potential, Life Sci. 1995, 56, 1845-1855. 

There is growing evidence that dietary curcumin possesses chemopreventive potential against mammary cancer. Dietary administration of 1% turmeric or 0.5% eth-anolic extract of turmeric inhibited DMBA-induced mammary carcinogenesis during the initiation as well as the postinitiation phase of carcinogenesis. Singletary... 

The first compounds demonstrating chemopreventive potential were found in plants such as broccoli and green tea. Today, chemoprevention refers to the use of both natural and synthetic compounds to inhibit carcinogenesis. 

Much attention has been drawn to search for new chemopreventive agents among stilbenoids. Combretastatins series have been studied well for their chemopreventive potential, especially combretastatin A-4 (816). It is... 

There is no evidence to support a causal association between selenium compounds and cancer in humans. In fact, some epidemiological and experimental evidence suggests that selenium exposure under certain conditions may contribute to a reduction in cancer risk. Currently, the chemopreventive potential of selenium is under research. Selenium sulfide and ethyl selenac are the only selenium compounds that have been shown to be carcinogenic upon oral administration in rodents however, significant exposure to these forms of selenium is extremely unlikely. 

Dingley, K.H. et al., Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes, Nutr. Cancer, 46, 212, 2003. 

Gerhauser C, You M, Liu J, Moriarty RM, Hawthorne M, Mehta RG, Moon RC, Pezzuto JM. Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces Phase 2 drug-metabolizing enzymes. Cancer Res 1997 57 272-278. 

FIGURE 35.1 Examples of spices with chemopreventive potential and their principal ingredients. 

Anti-Inflammatory Phytochemicals with Chemopreventive Potential... 

Apoptosis is a major mechanism by which many current synthetic anticancer and chemotherapeutic agents induce their effect. As such, apoptosis has emerged as an important mechanism by which dietary compounds may exhibit chemopreventive potential. Apoptosis may remove cells undergoing neoplastic transformation when other cellular defense systems have failed to block the carcinogenesis process upstream. Removing the neoplastic cells by induction of apoptosis represents a cornerstone of the chemopreventive paradigm [134]. 

Nanoformulated nutraceuticals such as polyphenols and fiavanoids, which are derived from medicinal plants, provide a new insight for cancer treatment. The mechanism of action of these dietary agents in chemoprevention has gained considerable interest in the area of cancer research. This review has presented several mechanisms explaining the chemopreventive potentials of curcumin, EGCG, resveratrol, saponin, silymarin, and GSE. Their ability to target specific... 

Isoflavones (2) could have their diverse activity such as cancer chemopreventive potential [21], anti-inflammatory activity as a non-steroidal anti-inflammatory agent [22], hormone adjustment effect [23], dietary phyto-oestrogens and bone density [24, 25] and phyto-oestrogens and cardiovascular disease risk [26]. 

Salim El, Fukushima S (2003) Chemopreventive potential of volatile oil from black cumin (Nigella saliva L.) seeds against rat colon carcinogenesis. Nutr Cancer 45 195 Schera JM, Burgessb EJ, Lorimerb SD, Perry NB (2002) A cytotoxic sesquiterpene and unprecedented sesquiterpene-bisbibenzyl compounds from the liverwort Schistochila glaucescens. Tetrahedron 58 7875... 

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