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And heterocyclic amines

The activating effect of a trichloromethyl group is seen in the 2-dechlorination reactions of 2-chloro-4,6-bis(trichloromethyl)-s-tria-zine (175) with arylsulfonylhydrazides (24 hr) and heterocyclic amines (3 hr) at 20° and with unbasifled primary and secondary alcohols (65°, 30 min). The 4,6-diphenyl or 4,6-bis(4-chlorophenyl) analogs do not react in this manner. ... [Pg.232]

PospfSil, J.i Aromatic and Heterocyclic Amines in Polymer Stabilization, Vol. 124, pp. 87-190. [Pg.214]

Weisburger JH (2002) Comments on the history and importance of aromatic and heterocyclic amines in public health. Mut Res 506-507 9-20... [Pg.29]

Compounds with an acidity constant, pK, in the range of 4 to 10, i.e. weak organic acids or bases, are present in two species forms at ambient pH. This pA a.i. range includes aromatic alcohols and thiols, carboxylic acids, aromatic amines and heterocyclic amines [15]. Conversely, alkyl-H and saturated alcohols do not undergo protonation/deprotonation in water (pA iw 14). [Pg.209]

Gorlewska-Roberts KM, Teitel CH, Lay JO, Jr., et al. Lactoperoxidase-catalyzed activation of carcinogenic aromatic and heterocyclic amines. Chem Res Toxicol 2004 17(12) 1659-1966. [Pg.104]

Polycyclic amines, such as a-aminoanthraquinone, and heterocyclic amines, such as aminophthalimide, aminobenzazoles, or aminoquinazolines are less interesting coupling components for azo pigments. [Pg.186]

Because of the higher CH acidity (by 7-8 pKa units) of alkylidene malonates (441), as compared with that of dialkyl malonates (87JA809), one-pot syntheses of alkylidene aminomethylenemalonates (442) could be carried out readily with a wide variety of primary and secondary aliphatic and cycloaliphatic amines, anilines, naphthylamines and heterocyclic amines, trialkyl orthoformate, and alkylidene malonates (83MI1 86MI9). It was proposed that the higher CH acidity of alkylidene malonates was a consequence of the electrostatic (dipole-dipole) repulsion effects... [Pg.114]

Modifications of the Bratton-Marshall method mentioned in Section IV.D.3.g can be used for sensitive spectrophotometric detection and determination of primary aromatic and heterocyclic amines. Thus, a simple spectrophotometric determination of the cardioprotective agent acadesine (142) was developed, to measure concentrations of the drug in plasma during intravenous infusion to patients undergoing coronary artery bypass graft surgery336. [Pg.1097]

Meats, charbroiled, smoked, or fried Many, largely polycycUc aromatic hydrocarbons such as benzo[a]pyrene, and heterocyclic amines... [Pg.334]

The antibacterial sulfonamide phthalazole 268 is obtained free of imide and bisamide side products (that occur upon reaction in solution or in the melt) if stoichiometric solid-state milling of the reactants 266 and 267 is performed for the acylation [95] (Scheme 38). Numerous solid arylamines and heterocyclic amines react correspondingly with phthalic anhydride upon stoichiometric milling and provide 100% yield without any workup requirement [22]. [Pg.141]

The fuel selected for use with HAN should be totally compatible and therefore, nitrate salts of amines are the natural choice for this purpose. Based on a study with aliphatic, aromatic and heterocyclic amines, aliphatic amines are considered a better choice and a formulation containing the nitrate salt of triethanolamine (TEA), that is, TEAN [(CH2OHCH2)3 NHNOJ is currently in use. HAN-based propellants consist of HAN, water and TEAN. Some typical formulations of LGP are given in Table 4.2 along with their properties. These three propellants differ from one another only in respect of the amount of water which they contain. [Pg.232]

Kim D, Guengerich FP. Cytochrome P450 activation of arylamines and heterocyclic amines. Annu Rev Pharmacol Toxicol 2005 45 27-49. [Pg.404]

Of the numerous reactions the most thoroughly studied is dehydrochlorination [12] (Scheme 2.3). Common dehydrochlorinating agents include alcoholic alkali [4], liquid ammonia [13], methylamine [13], LiCl in dimethylformamide (DMF) [14], MOH or M2CO3 (M = K or Na) in DMF [15] and tertiary and heterocyclic amines [16]. Moreover, some diaryltrichloroethanes, such as dichlordiphenyl-trichloroethane (DDT), may undergo thermal dehydrochlorination near 170-200 °C. [Pg.5]

Bis-substitution of stilbene produces stronger fluorescence and the bis-triazine derivatives of diaminostilbenes have proved to be the most successful brighteners for cellulosics, in particular, and polyamides (60MI11200). The variety of substitution permutations in (90) is almost endless and many primary and secondary homocyclic and heterocyclic amines, thiols and phenols have been used. Synthesis of such compounds is straightforward and utilizes the convenient selectivity to substitution of cyanuric chloride. 4,4 -Diaminostilbene-2,2 -disulfonic acid condenses readily at 0-5 °C with cyanuric chloride, under slightly acidic conditions. In this case cyanuric chloride behaves as a monofunctional acid chloride and, although some by-products are unavoidable, two molecules of cyanuric chloride condense... [Pg.338]

Few additions have been attempted using imines prepared from heterocyclic aldehydes and heterocyclic amines. In the one example reported l-(3-pyridyl)-5-(2-quinolyl)-l,2,3-triazoline is obtained in 70% yield after 21 hr.329... [Pg.284]

An enantioselective organocatalytic reductive amination has been achieved using Hantzsch ester for hydrogen transfer and compound (21) as catalyst. This mild and operationally simple fragment coupling has been accomplished with a wide range of ketones in combination with aryl and heterocyclic amines.359... [Pg.138]

Acetyl transferases Aromatic and heterocyclic amines, hydrazines, and sulfonamides... [Pg.50]


See other pages where And heterocyclic amines is mentioned: [Pg.925]    [Pg.290]    [Pg.89]    [Pg.241]    [Pg.165]    [Pg.114]    [Pg.291]    [Pg.221]    [Pg.14]    [Pg.247]    [Pg.576]    [Pg.209]    [Pg.280]    [Pg.152]    [Pg.165]    [Pg.61]    [Pg.121]    [Pg.147]    [Pg.55]   
See also in sourсe #XX -- [ Pg.872 ]




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