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DMBA-induced mammary carcinogenesis

Constantinou AI, Mehta R, Husband A. (2003) Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats. Fur J Cancer 39 1012-1018. [Pg.173]

Figure 4. Dietary fat and antioxidant influences on DMBA-induced mammary carcinogenesis. Figure 4. Dietary fat and antioxidant influences on DMBA-induced mammary carcinogenesis.
Table V. The effects of dietary fat concentration (4 or 20% corn oil) on DMBA-induced mammary carcinogenesis in control, ovariectomized, and ovariec-tomized-estrogen treated rats... Table V. The effects of dietary fat concentration (4 or 20% corn oil) on DMBA-induced mammary carcinogenesis in control, ovariectomized, and ovariec-tomized-estrogen treated rats...
There is growing evidence that dietary curcumin possesses chemopreventive potential against mammary cancer. Dietary administration of 1% turmeric or 0.5% eth-anolic extract of turmeric inhibited DMBA-induced mammary carcinogenesis during the initiation as well as the postinitiation phase of carcinogenesis. Singletary... [Pg.184]

L Abbe MR, Fischer PW, Chavez ER. 1989. Changes in selenium and antioxidant status during DMBA-induced mammary carcinogenesis in rats. J Nutr 119(5) 766-771. [Pg.360]

Constantinou, A.I. et al., Chemopreventive effects of soy protein and purified isoflavones on DMBA-induced mammary carcinogenesis in Sprague-Dawley rats, Nutr. Cancer, 41, 75, 2001. [Pg.297]

Rao, A.R. 1981. Inhibitory action of Asparagus racemosus on DMBA-induced mammary carcinogenesis in rats. Int.. Cancer 28(5) 607-610. [Pg.107]

As mentioned earlier that sesame lignans, especially sesamin and epi-sesamin, could influence the metabolism of polyunsaturated fatty acid and the production of prostaglandins. As prostaglandin is one of the most influential factors for mammary carcinogenesis, Hirose et al. (99) studied the effect of sesamin on dimethylbenz-anthracene (DMBA)-induced mammary cancer. Their results showed that sesamin at a dietary level of 0.2% considerably reduced the cumulative number and mean number of mammary cancer the effectiveness of sesamin was similar to a-tocopherol. [Pg.1204]

The furanoids, kahweol and cafestol, isolated from green coffee beans (4) have been found to induce increased GST activity and inhibit 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary tumor formation (9) and hamster cheek pouch carcinogenesis (10,11). The presence of the fiiran moiety was determined to be essential for enzyme induction. When the furan ring in cafestol was saturated by hydrogenation, its activity as a GST enzyme inducer was lost (S). [Pg.280]

Extracts of R. officinalis L. have been reported to inhibit experimental carcinogenesis. Dietary supplementation of rosemary extract significantly reduced the mammary tumor incidence and also inhibited covalent binding of DMBA to mammaiy epithelial cell DNA. Camosol appears to be partly responsible for the antitumorigenic activity of rosemary. Intraperitoneal injection of camosol as well as rosemary extract significantly decreased the number of DMBA-induced adenocarcinomas and the levels of DNA adducts in rat mammary gland compared with controls. ... [Pg.704]

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See also in sourсe #XX -- [ Pg.373 ]



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DMBA

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